Feasibility of interstitial stepping-source electronic brachytherapy to locally inoperable tumors

Abstract: Purpose: Radiotherapy is the mainstay in the treatment of locally inoperable tumors. Interstitial electronic needlebased kilovoltage brachytherapy (EBT) could be an economic alternative to high-dose-rate (HDR) brachytherapy or permanent seed implantation (PSI). In this work, we evaluated if locally inoperable tumors treated with PSI at ourinstitution may be suitable for EBT.
Material and methods: A total of 10 post-interventional computed tomography (CT) scans of patients, who received PSI and simulated stepping-source EBT applied with Intrabeam system and needle applicator were used. EBT treatment planning software with 3-dimensional image and projection of applicator were applied for designing trajectories and establishing dwell positions. Dwell position doses were summarized, and doses covering 90% of the target volume (D90) achieved with stepping-source EBT were compared to those of PSI. Additionally, conformality of dose distributions and total irradiation time were assessed using conformation number (CN) or conformal index (COIN).
Results: In all patients, D90 of EBT exceeded the prescribed dose or D90 of PSI on average by 4.7% or 21.3% relative to the prescribed dose, respectively. Mean number of trajectories was 5.0 for EBT and 6.9 for PSI. Average CN/COIN for EBT was 0.69, with a mean irradiation time of 27.8 minutes for standardized dose of 13 Gy.
Conclusions: Stepping-source EBT allowed for a conformal treatment of inoperable interstitial tumors with similar D90. Fewer trajectories were required for EBT in majority of cases

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Journal of contemporary brachytherapy. - 14, 5 (2020) , 480-486, ISSN: 2081-2841

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2021
• Creator: Ruder, Arne Mathias ; Inghelram, Laurens ; Schneider, Frank ; Sarria, Gustavo R. ; Hesser, Jürgen ; Bludau, Frederic ; Obertacke, Udo ; Wenz, Frederik ; Abo-Madyan, Yasser ; Giordano, Frank Anton

Further information

• DOI: 10.5114/jcb.2020.100381
• URN: urn:nbn:de:bsz:25-freidok-1745315
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 30.04.2025, 8:49 AM CEST