Enterolyin S, a Polythiazole‐containing Hemolytic Peptide from Enterococcus caccae
Abstract: The β‐hemolytic factor streptolysin S (SLS) is an important linear azol (in) e‐containing peptide (LAP) that contributes significantly to the virulence of Streptococcus pyogenes. Despite its discovery 85 years ago, SLS has evaded structural characterizing owing to its notoriously problematic physicochemical properties. Here, we report the discovery and characterization of a structurally analogous hemolytic peptide from Enterococcus caccae, termed enterolysin S (ELS). Through heterologous expression, site‐directed mutagenesis, chemoselective modification, and high‐resolution mass spectrometry, we found that ELS contains an intriguing contiguous octathiazole moiety. The discovery of ELS expands our knowledge of hemolytic LAPs by adding a new member to this virulence‐promoting family of modified peptides.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Enterolyin S, a Polythiazole‐containing Hemolytic Peptide from Enterococcus caccae ; day:24 ; month:05 ; year:2024 ; extent:6
ChemBioChem ; (24.05.2024) (gesamt 6)
- Creator
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Shi, Chengyou
Patel, Varshal A.
Mitchell, Douglas A.
Zhao, Huimin
- DOI
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10.1002/cbic.202400212
- URN
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urn:nbn:de:101:1-2405241438399.970013691275
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:44 AM CEST
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Associated
- Shi, Chengyou
- Patel, Varshal A.
- Mitchell, Douglas A.
- Zhao, Huimin
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