A[beta] seeding as a tool to study cerebral amyloidosis and associated pathology
Abstract: Misfolded proteins can form aggregates and induce a self-perpetuating process leading to the amplification and spreading of pathological protein assemblies. These misfolded protein assemblies act as seeds of aggregation. In an in vivo exogenous seeding model, both the features of seeds and the position at which seeding originates are precisely defined. Ample evidence from studies on intracerebal injection of amyloid-beta (Aβ)-rich brain extracts suggests that Aβ aggregation can be initiated by prion-like seeding. In this mini-review article, we will summarize the past and current literature on Aβ seeding in mouse models of AD and discuss its implementation as a tool to study cerebral amyloidosis and associated pathology
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Frontiers in molecular neuroscience. - 12 (2019) , 233, ISSN: 1662-5099
- Schlagwort
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Alzheimerkrankheit
Amyloidose
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2019
- Urheber
- DOI
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10.3389/fnmol.2019.00233
- URN
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urn:nbn:de:bsz:25-freidok-1514763
- Rechteinformation
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:57 MESZ
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Beteiligte
- Friesen, Marina
- Meyer-Lühmann, Melanie
- Universität
Entstanden
- 2019
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Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation
Growth Hormone and Cerebral Amyloidosis
Prion-like aspects of cerebral amyloidosis
A[beta] oligomers trigger and accelerate A[beta] seeding
Pathology of cerebral microcirculation
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Modulation of cerebral β-amyloidosis by myeloid cells
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TDP-43 pathology is associated with increased tau burdens and seeding
Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease
Cerebral angiography : normal anatomy and pathology
Remodeling Alzheimer-amyloidosis models by seeding
Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation
Growth Hormone and Cerebral Amyloidosis
Prion-like aspects of cerebral amyloidosis
A[beta] oligomers trigger and accelerate A[beta] seeding
Pathology of cerebral microcirculation
Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis
Modulation of cerebral β-amyloidosis by myeloid cells
Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology
TDP-43 pathology is associated with increased tau burdens and seeding
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Cerebral β-Amyloidosis [Beta-Amyloidosis] : regulation of Aβ levels and initiation and propagation of Aβ aggregation
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Prion-like aspects of cerebral amyloidosis
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Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease