Bioinspired Bone Seed 3D‐Printed Scaffold via Trapping Black Phosphorus Nanosheet for Bone Regeneration
Significance of endogenous mineralization in bone reconstruction is paramount, as it facilitates the accumulation of calcium ions for bone tissue deposition. However, conventional 3D‐printed scaffolds lack the capacity for calcium ion enrichment and mineralization, coupled with their low bone inductive activity. Inspired from the development of natural plant seeds, a biomimetic 3D printing scaffold is developed by implanting photosensitive black phosphorus “bone seeds” (BS), guiding a sequential process mirroring rooting (osteoblast recruitment), sprouting (fibrous callus mineralization), flowering (osseous callus formation), and fruiting (callus plasticity). BS were trapped onto porous 3D polycaprolactone (PCL) scaffolds with aminated surfaces via electrostatic interactions between phosphates and amino groups, creating the PCL‐BS scaffold that can actively capture calcium ions for accelerating the endogenous regeneration of critical bone defects. In vitro and in vivo experiments show that the PCL‐BS scaffold has good biocompatibility and strong osteogenic ability for rapid new bone regeneration under near‐infrared (NIR) stimulation. In addition, whole transcriptome sequencing analysis is performed to reveal the transcriptomic mechanism of BS involved in signal transduction and network regulation during bone regeneration. This NIR light‐regulated biomimetic BS inspired by seed planting, introduces a pioneering concept in the design of 3D printing bone repair scaffolds.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Bioinspired Bone Seed 3D‐Printed Scaffold via Trapping Black Phosphorus Nanosheet for Bone Regeneration ; day:11 ; month:05 ; year:2024 ; extent:13
Small science ; (11.05.2024) (gesamt 13)
- Urheber
-
Cai, Zhengwei
Chen, Zhijie
Tang, Yuan
Cheng, Liang
Qiu, Minglong
Wang, Ningtao
Jiang, Wei
Li, Zhanchun
Pereira, Catarina Leite
Zhang, Yunhai
Sarmento, Bruno
Cui, Wenguo
- DOI
-
10.1002/smsc.202300357
- URN
-
urn:nbn:de:101:1-2405111417057.890919519298
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:49 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Cai, Zhengwei
- Chen, Zhijie
- Tang, Yuan
- Cheng, Liang
- Qiu, Minglong
- Wang, Ningtao
- Jiang, Wei
- Li, Zhanchun
- Pereira, Catarina Leite
- Zhang, Yunhai
- Sarmento, Bruno
- Cui, Wenguo
Ähnliche Objekte (12)
Nitric Oxide‐Releasing Bioinspired Scaffold for Exquisite Regeneration of Osteoporotic Bone via Regulation of Homeostasis
Optimization of bone scaffold porosity distributions
Mechano-biological computer model of scaffold-supported bone regeneration : effect of bone graft and scaffold structure on large bone defect tissue patterning
Multiphasic bone-ligament-bone integrated scaffold enhances ligamentization and graft-bone integration after anterior cruciate ligament reconstruction
Bioinspired fabrication of biosilica-based bone substitution materials
Biomimetic bone-periosteum scaffold for spatiotemporal regulated innervated bone regeneration and therapy of osteosarcoma
Synthetic Calcite as a Scaffold for Osteoinductive Bone Substitutes
A Biomimetic Multifunctional Scaffold for Infectious Vertical Bone Augmentation
Novel bone repairing scaffold consisting of bone morphogenetic Protein-2 and human Beta Defensin-3
Comparison of the 3D-microstructure between alveolar and iliac bone for enhanced bioinspired bone graft substitutes
In vivo safety assessment of a bio-inspired bone adhesive
Bio-inspired structured composites for load-bearing bone graft substitution
Nitric Oxide‐Releasing Bioinspired Scaffold for Exquisite Regeneration of Osteoporotic Bone via Regulation of Homeostasis
Optimization of bone scaffold porosity distributions
Mechano-biological computer model of scaffold-supported bone regeneration : effect of bone graft and scaffold structure on large bone defect tissue patterning
Multiphasic bone-ligament-bone integrated scaffold enhances ligamentization and graft-bone integration after anterior cruciate ligament reconstruction
Bioinspired fabrication of biosilica-based bone substitution materials
Biomimetic bone-periosteum scaffold for spatiotemporal regulated innervated bone regeneration and therapy of osteosarcoma
Synthetic Calcite as a Scaffold for Osteoinductive Bone Substitutes
A Biomimetic Multifunctional Scaffold for Infectious Vertical Bone Augmentation
Novel bone repairing scaffold consisting of bone morphogenetic Protein-2 and human Beta Defensin-3
Comparison of the 3D-microstructure between alveolar and iliac bone for enhanced bioinspired bone graft substitutes
In vivo safety assessment of a bio-inspired bone adhesive
Bio-inspired structured composites for load-bearing bone graft substitution
Nitric Oxide‐Releasing Bioinspired Scaffold for Exquisite Regeneration of Osteoporotic Bone via Regulation of Homeostasis
Optimization of bone scaffold porosity distributions
Mechano-biological computer model of scaffold-supported bone regeneration : effect of bone graft and scaffold structure on large bone defect tissue patterning
Multiphasic bone-ligament-bone integrated scaffold enhances ligamentization and graft-bone integration after anterior cruciate ligament reconstruction
Bioinspired fabrication of biosilica-based bone substitution materials
Biomimetic bone-periosteum scaffold for spatiotemporal regulated innervated bone regeneration and therapy of osteosarcoma
Synthetic Calcite as a Scaffold for Osteoinductive Bone Substitutes
A Biomimetic Multifunctional Scaffold for Infectious Vertical Bone Augmentation
Novel bone repairing scaffold consisting of bone morphogenetic Protein-2 and human Beta Defensin-3
Comparison of the 3D-microstructure between alveolar and iliac bone for enhanced bioinspired bone graft substitutes
In vivo safety assessment of a bio-inspired bone adhesive