Advancing Topoisomerase Research Using DNA Nanotechnology

Abstract: In this Perspective, the use of DNA nanotechnology is explored as a powerful tool for studying a family of enzymes known as topoisomerases. These enzymes regulate DNA topology within a living cell and play a major role in the pharmaceutical field, serving as anti‐cancer and anti‐bacterial targets. This Perspective will provide a short historical overview of the methods employed in studying these enzymes and emphasizing recent advancements in assays using DNA nanotechnology. These innovations have substantially improved accuracy and expanded the understanding of enzyme activity. This perspective will showcase the versatile utility of DNA nanotechnology in advancing scientific knowledge and its application in exploring new drug candidates, particularly in the study of topoisomerase enzymes.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Advancing Topoisomerase Research Using DNA Nanotechnology ; day:11 ; month:11 ; year:2024 ; extent:9 ; Small Methods ; (11.11.2024) (gesamt 9)

Contributors, Places and Time

• Creator: Yesodi, Doron ; Katz, Adi ; Weizmann, Yossi

Further information

• DOI: 10.1002/smtd.202401113
• URN: urn:nbn:de:101:1-2411111328345.707397338364
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST