Total Synthesis of Bulgarein
Abstract: Here we report an efficient and short total synthesis of bulgarein (1), a natural compound from Bulgaria inquinans with cytotoxic activity. Key steps in the total synthesis are a suzuki‐miyaura coupling reaction of two substituted naphthalene derivates followed by a polyphosphoric acid (PPA) mediated condensation reaction to form the benzo[j]fluoranthene skeleton. Bulgarein (1) was achieved over 4 steps with an overall yield of 25 %.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Total Synthesis of Bulgarein ; volume:2022 ; number:16 ; year:2022 ; extent:4
European journal of organic chemistry ; 2022, Heft 16 (2022) (gesamt 4)
- Creator
- DOI
-
10.1002/ejoc.202101576
- URN
-
urn:nbn:de:101:1-2022042215224260187146
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:38 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Swieca, Patrick
- Spiteller, Peter
Other Objects (12)
Total synthesis of dictyostatin
Total Synthesis of (−)-Gephyrotoxin
Total Synthesis of Linoxepin
Total Synthesis of Sespenine
Total synthesis of ochnaflavone
Total Synthesis of (+)-Maritimol
Total Synthesis of (-)-Agelastatin
Total Synthesis of Pandamarine
Total Synthesis of (+)-Hyperforin
Total Synthesis of (±)-Daphenylline
Total Synthesis of (+)-Monensin
Total Synthesis of (±)-Khusimone
Total synthesis of dictyostatin
Total Synthesis of (−)-Gephyrotoxin
Total Synthesis of Linoxepin
Total Synthesis of Sespenine
Total synthesis of ochnaflavone
Total Synthesis of (+)-Maritimol
Total Synthesis of (-)-Agelastatin
Total Synthesis of Pandamarine
Total Synthesis of (+)-Hyperforin
Total Synthesis of (±)-Daphenylline
Total Synthesis of (+)-Monensin
Total Synthesis of (±)-Khusimone
Total synthesis of dictyostatin
Total Synthesis of (−)-Gephyrotoxin
Total Synthesis of Linoxepin
Total Synthesis of Sespenine
Total synthesis of ochnaflavone
Total Synthesis of (+)-Maritimol
Total Synthesis of (-)-Agelastatin
Total Synthesis of Pandamarine
Total Synthesis of (+)-Hyperforin
Total Synthesis of (±)-Daphenylline
Total Synthesis of (+)-Monensin