It is time anti-CGRP monoclonal antibodies be considered first-line prophylaxis for migraine

Abstract: The result of more than thirty years of research, anti-CGRP monoclonal antibodies are currently the state of the art for migraine preventive therapy. Their efficacy and safety, supported by an already large and growing body of evidence, are added by many other advantages: an early onset of action, favorable posology, negligible pharmacological interaction, and a broad-reaching efficacy in many challenging clinical contexts. When compared to standard prophylactics, these novel medications seem at least as efficacious, clearly more tolerable and, consequently, with a superior adherence profile. Furthermore, recently published analyses indicate that they are cost-effective, especially among those with chronic migraine. Yet, current guidelines endorse their use only after multiple other preventives have failed or have been deemed not tolerable. Although this recommendation may have been sensible at first, the now available data strongly point that time has come for anti-CGRP monoclonal antibodies to be acknowledged as first-line treatments for migraine patients with severe disability. For these individuals, delaying treatment until several other alternatives have failed incurs in significant losses, both economically and to many relevant aspects of their lives.

Object Details

• Alternative title: Já é tempo de os anticorpos monoclonais anti-CGRP serem reconhecidos como profilaxia de primeira linha para a migrânea
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: It is time anti-CGRP monoclonal antibodies be considered first-line prophylaxis for migraine ; volume:80 ; number:S 05 ; year:2022 ; pages:218-226 ; 05 ; Arquivos de neuro-psiquiatria ; 80, Heft S 05 (2022), 218-226, 05

Contributors, Places and Time

• Contributor: Kubota, Gabriel Taricani

Further information

• DOI: 10.1590/0004-282X-ANP-2022-S112
• URN: urn:nbn:de:101:1-2023032311352676441514
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:57 AM CEST