Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome
Abstract: This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely and repeatedly distributed among 3,762 human proteins implicated in crucial fundamental cellular functions. The data can have implications for anti-RSV vaccines. Indeed, the high level of molecular mimicry can lead to cross-reactivity and autoimmunity, and invites to follow safer vaccinal protocols based on pentapeptide sequences uniquely present in the viral antigen.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome ; volume:10 ; number:01 ; year:2023 ; pages:19-21
Global medical genetics ; 10, Heft 01 (2023), 19-21
- Contributor
- DOI
-
10.1055/s-0043-1761489
- URN
-
urn:nbn:de:101:1-2023031611203913682882
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:55 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Other Objects (12)
Das Respiratory-Syncytial-<RS>-Virus-Antigen
Severe Respiratory Syncytial Virus Infection
The Lewis Y antigen : Recognition and Mimicry
Das Respiratory syncytial Virus : Eine Durchseuchungsstudie
An update on respiratory syncytial virus
Heliox reduces respiratory system resistance in respiratory syncytial virus induced respiratory failure
Human Respiratory Syncytial Virus Detected in Mountain Gorilla Respiratory Outbreaks
Immunoprophylaxis of respiratory syncytial virus: global experience
Interventions against the Respiratory Syncytial Virus Infection
Patient equity and respiratory syncytial virus Immunoprophylaxis
Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line
Does nirsevimab prevent lower respiratory infections caused by respiratory syncytial virus?
Das Respiratory-Syncytial-<RS>-Virus-Antigen
Severe Respiratory Syncytial Virus Infection
The Lewis Y antigen : Recognition and Mimicry
Das Respiratory syncytial Virus : Eine Durchseuchungsstudie
An update on respiratory syncytial virus
Heliox reduces respiratory system resistance in respiratory syncytial virus induced respiratory failure
Human Respiratory Syncytial Virus Detected in Mountain Gorilla Respiratory Outbreaks
Immunoprophylaxis of respiratory syncytial virus: global experience
Interventions against the Respiratory Syncytial Virus Infection
Patient equity and respiratory syncytial virus Immunoprophylaxis
Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line
Does nirsevimab prevent lower respiratory infections caused by respiratory syncytial virus?
Das Respiratory-Syncytial-<RS>-Virus-Antigen
Severe Respiratory Syncytial Virus Infection
The Lewis Y antigen : Recognition and Mimicry
Das Respiratory syncytial Virus : Eine Durchseuchungsstudie
An update on respiratory syncytial virus
Heliox reduces respiratory system resistance in respiratory syncytial virus induced respiratory failure
Human Respiratory Syncytial Virus Detected in Mountain Gorilla Respiratory Outbreaks
Immunoprophylaxis of respiratory syncytial virus: global experience
Interventions against the Respiratory Syncytial Virus Infection
Patient equity and respiratory syncytial virus Immunoprophylaxis
Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line