Detection of local recurrent prostate cancer after radical prostatectomy in terms of salvage radiotherapy using dynamic contrast enhanced-MRI without endorectal coil

Abstract: Purpose
To evaluate the value of dynamic contrast enhanced Magnetic Resonance Imaging (DCE-MRI) without endorectal coil (EC) in the detection of local recurrent prostate cancer (PC) after radical prostatectomy (RP).

Material and methods
Thirty-three patients with recurrent PC underwent DCE-MRI without EC before salvage radiotherapy (RT). At median 15 (mean 16±4.9, range 12–27) months after completion of RT all patients showed complete biochemical response. Additional follow up post RT DCE-MRI scans were available. Prostate specific antigen (PSA) levels at the time of imaging were correlated to the imaging findings.

Results
In 22/33 patients (67%) early contrast enhancing nodules were detected in the post-prostatectomy fossa on pre-RT DCE-MRI images. The average pre-RT PSA level of the 22 patients with positive pre-RT DCE-MRI findings was significantly higher (mean, 0.74±0.64 ng/mL) compared to the pre-RT PSA level of the 11 patients with negative pre-RT DCE-MRI (mean, 0.24±0.13 ng/mL) (p<0.001). All post-RT DCE-MRI images showed complete resolution of initial suspicious lesions. A pre-RT PSA cut-off value of ≥0.54 ng/ml readily predicted a positive DCE-MRI finding.

Conclusions
This is the first study that shows that DCE-MRI without EC can detect local recurrent PC with an estimated accuracy of 83% at low PSA levels. All false negative DCE-MRI scans were detected using a PSA cut-off of ≥0.54 ng/mL

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Radiation Oncology. 7 (2012), 185, DOI 10.1186/1748-717X-7-185, ISSN: 1748-717X

Classification and Topics

• Keyword: Prostatakrebs ; Prostataresektion

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2017
• Creator: Rischke, Hans Christian ; Schäfer, Arnd-Oliver ; Nestle, Ursula ; Volegova-Neher, Natalja ; Henne, Karl ; Schultze-Seemann, Wolfgang ; Langer, Mathias ; Grosu, Anca-Ligia
• Contributor: Universitätsklinikum Freiburg. Department für Radiologische Diagnostik und Therapie ; Albert-Ludwigs-Universität Freiburg. Medizinische Fakultät ; Universitätsklinikum Freiburg. Klinik für Urologie

Further information

• DOI: 10.1186/1748-717X-7-185
• URN: urn:nbn:de:bsz:25-freidok-124449
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:46 PM CET