Light‐Controllable Binary Switch Activation of CAR T Cells
Abstract: Major challenges to chimeric antigen receptor (CAR) T cell therapies include uncontrolled immune activity, off‐tumor toxicities and tumor heterogeneity. To overcome these challenges, we engineered CARs directed against small molecules. By conjugating the same small molecule to distinct tumor‐targeting antibodies, we show that small molecule specific‐CAR T cells can be redirected to different tumor antigens. Such binary switches allow control over the degree of CAR T cell activity and enables simultaneous targeting of multiple tumor‐associated antigens. We also demonstrate that ultraviolet light‐sensitive caging of small molecules blocks CAR T cell activation. Exposure to ultraviolet light, uncaged small molecules and restored CAR T cell‐mediated killing. Together, our data demonstrate that a light‐sensitive caging system enables an additional level of control over tumor cell killing, which could improve the therapeutic index of CAR T cell therapies.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Light‐Controllable Binary Switch Activation of CAR T Cells ; day:21 ; month:02 ; year:2022 ; extent:1
ChemMedChem ; (21.02.2022) (gesamt 1)
- Creator
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Kobayashi, Aya
Nobili, Alberto
Neier, Steven C.
Sadiki, Amissi
Distel, Robert
Zhou, Zhaohui Sunny
Novina, Carl D.
- DOI
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10.1002/cmdc.202100722
- URN
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urn:nbn:de:101:1-2022022214164956664436
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Kobayashi, Aya
- Nobili, Alberto
- Neier, Steven C.
- Sadiki, Amissi
- Distel, Robert
- Zhou, Zhaohui Sunny
- Novina, Carl D.
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