Nutrient-gene interactions: a single nutrient and hundreds of target genes
Abstract: Based on the effects of a selective experimental zinc deficiency in a rodent model we explore the use of transcriptome profiling for assessing nutrient-gene interactions in the liver at the molecular and cellular levels. Zinc deficiency caused pleiotropic alterations in mRNA/protein levels of hundreds of genes. In the context of observed metabolic alterations in hepatic metabolism, possible mechanisms are discussed for how a low zinc status may be sensed and transmitted into changes in various metabolic pathways. However, it also becomes obvious that analysis of such complex nutrient-gene interactions beyond the descriptional level is a real challenge for systems biology.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Nutrient-gene interactions: a single nutrient and hundreds of target genes ; volume:385 ; number:7 ; year:2004 ; pages:571-583
Biological chemistry ; 385, Heft 7 (2004), 571-583
- Creator
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Daniel, H.
Dieck, H. tom
- DOI
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10.1515/BC.2004.071
- URN
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urn:nbn:de:101:1-2406121635259.111390355760
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:56 AM CEST
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Associated
- Daniel, H.
- Dieck, H. tom
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