Autonomous Ultrafast Self‐Healing Hydrogels by pH‐Responsive Functional Nanofiber Gelators as Cell Matrices

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Abstract: The synthesis of hybrid hydrogels by pH‐controlled structural transition with exceptional rheological properties as cellular matrix is reported. “Depsi” peptide sequences are grafted onto a polypeptide backbone that undergo a pH‐induced intramolecular O–N–acyl migration at physiological conditions affording peptide nanofibers (PNFs) as supramolecular gelators. The polypeptide–PNF hydrogels are mechanically remarkably robust. They reveal exciting thixotropic behavior with immediate in situ recovery after exposure to various high strains over long periods and self‐repair of defects by instantaneous reassembly. High cytocompatibility, convenient functionalization by coassembly, and controlled enzymatic degradation but stability in 2D and 3D cell culture as demonstrated by the encapsulation of primary human umbilical vein endothelial cells and neuronal cells open many attractive opportunities for 3D tissue engineering and other biomedical applications.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Autonomous Ultrafast Self‐Healing Hydrogels by pH‐Responsive Functional Nanofiber Gelators as Cell Matrices ; volume:31 ; number:2 ; year:2019 ; extent:7
Advanced materials ; 31, Heft 2 (2019) (gesamt 7)

Creator: Gačanin, Jasmina
Hedrich, Jana
Sieste, Stefanie
Glaßer, Gunnar
Lieberwirth, Ingo
Schilling, Corinna
Fischer, Stephan
Barth, Holger
Knöll, Bernd
Synatschke, Christopher V.
Weil, Tanja

DOI: 10.1002/adma.201805044

URN: urn:nbn:de:101:1-2022080106531560570270

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:26 AM CEST

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Associated

Gačanin, Jasmina
Hedrich, Jana
Sieste, Stefanie
Glaßer, Gunnar
Lieberwirth, Ingo
Schilling, Corinna
Fischer, Stephan
Barth, Holger
Knöll, Bernd
Synatschke, Christopher V.
Weil, Tanja

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