IL‐1β Is an Androgen‐Responsive Target in Macrophages for Immunotherapy of Prostate Cancer
Abstract: Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor in driving the growth of prostate cancer (PCa) epithelial cells. However, the understanding of the role of androgen in PCa‐infiltrated immune cells and the impact of androgen deprivation therapy (ADT), the first‐line treatment for advanced PCa, on the PCa immune microenvironment remains limited. On the other hand, immune checkpoint blockade has revolutionized the treatment of certain cancer types, but fails to achieve any benefit in advanced PCa, due to an immune suppressive environment. In this study, it is reported that AR signaling pathway is evidently activated in tumor‐associated macrophages (TAMs) of PCa both in mice and humans. AR acts as a transcriptional repressor for IL1B in TAMs. ADT releases the restraint of AR on IL1B and therefore leads to an excessive expression and secretion of IL‐1β in TAMs. IL‐1β induces myeloid‐derived suppressor cells (MDSCs) accumulation that inhibits the activation of cytotoxic T cells, leading to the immune suppressive microenvironment. Critically, anti‐IL‐1β antibody coupled with ADT and the immune checkpoint inhibitor anti‐PD‐1 antibody exerts a stronger anticancer effect on PCa following castration. Together, IL‐1β is an important androgen‐responsive immunotherapeutic target for advanced PCa.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
IL‐1β Is an Androgen‐Responsive Target in Macrophages for Immunotherapy of Prostate Cancer ; day:24 ; month:04 ; year:2023 ; extent:15
Advanced science ; (24.04.2023) (gesamt 15)
- Creator
-
Wang, Deng
Cheng, Chaping
Chen, Xinyu
Wang, Jinming
Liu, Kaiyuan
Jing, Na
Xu, Penghui
Xi, Xialian
Sun, Yujiao
Ji, Zhongzhong
Zhao, Huifang
He, Yuman
Zhang, Kai
Du, Xinxing
Dong, Baijun
Fang, Yuxiang
Zhang, Pengcheng
Qian, Xueming
Xue, Wei
Gao, Wei‐Qiang
Zhu, Helen He
- DOI
-
10.1002/advs.202206889
- URN
-
urn:nbn:de:101:1-2023042515342764827865
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:49 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wang, Deng
- Cheng, Chaping
- Chen, Xinyu
- Wang, Jinming
- Liu, Kaiyuan
- Jing, Na
- Xu, Penghui
- Xi, Xialian
- Sun, Yujiao
- Ji, Zhongzhong
- Zhao, Huifang
- He, Yuman
- Zhang, Kai
- Du, Xinxing
- Dong, Baijun
- Fang, Yuxiang
- Zhang, Pengcheng
- Qian, Xueming
- Xue, Wei
- Gao, Wei‐Qiang
- Zhu, Helen He
Other Objects (12)
Design, synthesis and pharmacological studies of novel multivalent and -funtional anti-Alzheimer's disease agents
Molecular beam epitaxy growth and structural property of self-assembled InAs quantum dots on GaAs
Molecular beam epitaxy growth and structural property of self-assembled InAs quantum dots on GaAs
Mining real estate ads and property transactions for building and amenity data acquisition
How natural walking changes occipital alpha oscillations and concurrently modulates cognitive processes
The crystal structure of catena -poly ((1,10-phenanthroline-κ 2 N, N ′)-(μ 3 -2-hydroxybenzene-1,3-dicarboxylato-κ 5 O, O ′: O ″, O ‴: O ‴) cadmium (II)), C 20 H 12 CdN 2 O 5
The crystal structure of bis (μ 2 -biphenyl-2,2′-dicarboxylato)-diaqua-bis (nitrato)-bis (2,2′:6′,2′′-terpyridine) dineodymium (III), C 46 H 32 I 2 N 8 Nd 2 O 16
SUSY’s Ladder: reframing sequestering at Large Volume
Evaluation of biophysical factors driving temporal variations in carbon gain, water use and yield production in rice
ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients
New conjugated polymers based on benzodifuranone and diketopyrrolopyrrole
Moist‐Defined Polymers with Tunable Multisteady Mechano‐Responsiveness Enabled by Imine‐Coordinated Boroxine
Design, synthesis and pharmacological studies of novel multivalent and -funtional anti-Alzheimer's disease agents
Molecular beam epitaxy growth and structural property of self-assembled InAs quantum dots on GaAs
Molecular beam epitaxy growth and structural property of self-assembled InAs quantum dots on GaAs
Mining real estate ads and property transactions for building and amenity data acquisition
How natural walking changes occipital alpha oscillations and concurrently modulates cognitive processes
The crystal structure of catena -poly ((1,10-phenanthroline-κ 2 N, N ′)-(μ 3 -2-hydroxybenzene-1,3-dicarboxylato-κ 5 O, O ′: O ″, O ‴: O ‴) cadmium (II)), C 20 H 12 CdN 2 O 5
The crystal structure of bis (μ 2 -biphenyl-2,2′-dicarboxylato)-diaqua-bis (nitrato)-bis (2,2′:6′,2′′-terpyridine) dineodymium (III), C 46 H 32 I 2 N 8 Nd 2 O 16
SUSY’s Ladder: reframing sequestering at Large Volume
Evaluation of biophysical factors driving temporal variations in carbon gain, water use and yield production in rice
ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients
New conjugated polymers based on benzodifuranone and diketopyrrolopyrrole
Moist‐Defined Polymers with Tunable Multisteady Mechano‐Responsiveness Enabled by Imine‐Coordinated Boroxine
Design, synthesis and pharmacological studies of novel multivalent and -funtional anti-Alzheimer's disease agents
Molecular beam epitaxy growth and structural property of self-assembled InAs quantum dots on GaAs
Molecular beam epitaxy growth and structural property of self-assembled InAs quantum dots on GaAs
Mining real estate ads and property transactions for building and amenity data acquisition
How natural walking changes occipital alpha oscillations and concurrently modulates cognitive processes
The crystal structure of catena -poly ((1,10-phenanthroline-κ 2 N, N ′)-(μ 3 -2-hydroxybenzene-1,3-dicarboxylato-κ 5 O, O ′: O ″, O ‴: O ‴) cadmium (II)), C 20 H 12 CdN 2 O 5
The crystal structure of bis (μ 2 -biphenyl-2,2′-dicarboxylato)-diaqua-bis (nitrato)-bis (2,2′:6′,2′′-terpyridine) dineodymium (III), C 46 H 32 I 2 N 8 Nd 2 O 16
SUSY’s Ladder: reframing sequestering at Large Volume
Evaluation of biophysical factors driving temporal variations in carbon gain, water use and yield production in rice
ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients
New conjugated polymers based on benzodifuranone and diketopyrrolopyrrole