Immunoregulatory functions of immune complexes in vaccine and therapy
Abstract: Clinical and experimental preparations of IgG/soluble antigen complexes, as well as those formed following antibody therapy in vivo, are multifaceted immune regulators. These immune complexes (ICs) have been tested in humans and animal models, mostly in forms of experimental or clinical vaccination, for at least a century. With intensified research on Fcγ receptor‐mediated immune modulation, as well as with immune complex‐directed antigen processing, presentation, and inflammatory responses, there are renewed interests of using ICs in vaccines and immunotherapies. Currently, IC‐based immune therapy has been broadly experimented in HBV and HIV viral infection control and antitumor treatments. However, mechanistic insights of IC‐based treatments are relatively recent subjects of study; strong efforts are needed to establish links to connect laboratory findings with clinical practices. This review covers the history, mechanisms, and in vivo outcomes of this safe and effective therapeutic tool, with a clear aim to bridge laboratory findings with evolving clinical applications.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Immunoregulatory functions of immune complexes in vaccine and therapy ; volume:8 ; number:10 ; year:2016 ; pages:1120-1133 ; extent:14
EMBO molecular medicine / European Molecular Biology Organization ; 8, Heft 10 (2016), 1120-1133 (gesamt 14)
- Urheber
-
Wen, Yu‐mei
Mu, Libing
Shi, Yan
- DOI
-
10.15252/emmm.201606593
- URN
-
urn:nbn:de:101:1-2022111007164107025056
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:46 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Wen, Yu‐mei
- Mu, Libing
- Shi, Yan
Ähnliche Objekte (12)
Foro Sobre Relaciones Entre China y América Latina en el Contexto de la Comunidad de Futuro Compartido para la Humanidad
Interacciones Sino-Iberoamericanas en 2022
Special Issue on Healthcare Mechatronics
A Novel Interface Agent for Preparation of High Gas Barrier Organic Montmorillonite/Brominated Butyl Rubber Nanocomposites
Nano fertilizer synergist effects on nitrogen utilization and related gene expression in wheat
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
A Transient Behavior Study of Polymer Electrolyte Fuel Cells with Cyclic Current Profiles
Inhibition Mechanism of the Interface Reaction in the Molten Pool of SiCp/Al Composites by Pulsed Laser Welding with Powder-Filling
A high-sensitivity rotatable 3D displacement sensor
Effect of nano-calcium carbonate on morphology, antioxidant enzyme activity and photosynthetic parameters of wheat (Triticum aestivum L.) seedlings
The utility of initial procalcitonin and procalcitonin clearance for prediction of bacterial infection and outcome in critically ill patients with autoimmune diseases: a prospective observational study
Optimization Study on Expansion Energy Used Air-Powered Vehicle with Pneumatic-Hydraulic Transmission
Foro Sobre Relaciones Entre China y América Latina en el Contexto de la Comunidad de Futuro Compartido para la Humanidad
Interacciones Sino-Iberoamericanas en 2022
Special Issue on Healthcare Mechatronics
A Novel Interface Agent for Preparation of High Gas Barrier Organic Montmorillonite/Brominated Butyl Rubber Nanocomposites
Nano fertilizer synergist effects on nitrogen utilization and related gene expression in wheat
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
A Transient Behavior Study of Polymer Electrolyte Fuel Cells with Cyclic Current Profiles
Inhibition Mechanism of the Interface Reaction in the Molten Pool of SiCp/Al Composites by Pulsed Laser Welding with Powder-Filling
A high-sensitivity rotatable 3D displacement sensor
Effect of nano-calcium carbonate on morphology, antioxidant enzyme activity and photosynthetic parameters of wheat (Triticum aestivum L.) seedlings
The utility of initial procalcitonin and procalcitonin clearance for prediction of bacterial infection and outcome in critically ill patients with autoimmune diseases: a prospective observational study
Optimization Study on Expansion Energy Used Air-Powered Vehicle with Pneumatic-Hydraulic Transmission
Foro Sobre Relaciones Entre China y América Latina en el Contexto de la Comunidad de Futuro Compartido para la Humanidad
Interacciones Sino-Iberoamericanas en 2022
Special Issue on Healthcare Mechatronics
A Novel Interface Agent for Preparation of High Gas Barrier Organic Montmorillonite/Brominated Butyl Rubber Nanocomposites
Nano fertilizer synergist effects on nitrogen utilization and related gene expression in wheat
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
A Transient Behavior Study of Polymer Electrolyte Fuel Cells with Cyclic Current Profiles
Inhibition Mechanism of the Interface Reaction in the Molten Pool of SiCp/Al Composites by Pulsed Laser Welding with Powder-Filling
A high-sensitivity rotatable 3D displacement sensor
Effect of nano-calcium carbonate on morphology, antioxidant enzyme activity and photosynthetic parameters of wheat (Triticum aestivum L.) seedlings
The utility of initial procalcitonin and procalcitonin clearance for prediction of bacterial infection and outcome in critically ill patients with autoimmune diseases: a prospective observational study