Bone morphogenetic protein in the repair of cerebrospinal fluid leak after transsphenoidal surgery
Background: Recurrent cerebrospinal fluid (CSF) leak carries significant morbidity. We sought to demonstrate that bone morphogenetic protein (BMP) use is effective and safe for the repair of recurrent CSF leak after a transsphenoidal pituitary tumor resection (TSPTR). Materials and Methods: We reviewed charts and radiographic data of consecutive patients who underwent BMP repair of recurrent CSF leak after TSPTR from January 2010 to June 2015 and who failed previous multilayer closure. We detailed the technique for constructing and placing a BMP-DuraGen patch for the repair. The primary variables include postoperative computed tomography/magnetic resonance imaging (CT/MRI) evidence of ectopic bone growth or inflammation, newly diagnosed systemic neoplasm within 1 year, and recurrent CSF leak. Secondary outcome is the length of stay after BMP repair. All patients were followed up radiographically and through phone interview. Results: Four patients underwent BMP repair of recurrent CSF leak after TSPTR. The average postoperative CT/MRI interval was 22 months. Postoperative CT/MRI revealed no ectopic bone formation or inflammatory changes around the site of BMP application. There was no recurrence of CSF leak or newly diagnosed neoplasm from both chart review and phone interview. Conclusions: We demonstrate that the use of BMP is a safe and an effective treatment in the repair of recurrent CSF leaks after TSPTR.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Bone morphogenetic protein in the repair of cerebrospinal fluid leak after transsphenoidal surgery ; volume:14 ; number:02 ; year:2019 ; pages:607-611
Asian journal of neurosurgery ; 14, Heft 02 (2019), 607-611
- Contributor
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Slavnic, Dejan
Cook, Richard
Bahoura, Matthew
Paik, Gijong
Tong, Doris
Houseman, Clifford
Barrett, Ryan
Soo, Teck-Mun
- DOI
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10.4103/ajns.AJNS_130_18
- URN
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urn:nbn:de:101:1-2022111711511502705930
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Slavnic, Dejan
- Cook, Richard
- Bahoura, Matthew
- Paik, Gijong
- Tong, Doris
- Houseman, Clifford
- Barrett, Ryan
- Soo, Teck-Mun
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