Hypothesis: Entrapment of lipoprotein particles in the brain causes Alzheimer’s disease

Abstract: We present for consideration a hypothesis that impaired movement of lipoprotein particles in the extracellular space in the brain in ageing is central to and causes all the key pathophysiological features of Alzheimer’s disease (AD). The role of lipoprotein particles is to transport cholesterol from glial cells, where it is synthesised, to neurons, which require cholesterol for synaptic plasticity. The lipoprotein particles have a cholesterol-containing hydrophobic core, in which amyloid-β (Aβ) can be solubilised. The core is surrounded by a hydrophilic surface containing apolipoprotein E (APOE) which, as neurons bear receptors for APOE, determines the destination of the particles. The problem arises because the extracellular space is a narrow cleft, barely wider than the lipoprotein particles themselves, which they have to navigate in order to perform their crucial cholesterol-transporting function. We explain how lipoprotein particles could become trapped in the ageing extracellu.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3459

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Hypothesis: Entrapment of lipoprotein particles in the brain causes Alzheimer’s disease ; volume:2 ; day:02 ; month:11 ; year:2021 ; Free Neuropathology ; 2 (02.11.2021)

Contributors, Places and Time

• Creator: Boche, Delphine ; Nicoll, James AR

Further information

• DOI: 10.17879/freeneuropathology-2021-3459
• URN: urn:nbn:de:hbz:6:3-freeneuropathology-2021-36539
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:31 AM CEST