HLA‐matched allogeneic anti‐CD19 CAR‐T therapy in treating a relapsed/refractory acute lymphoblastic leukemia patient with high tumor burden
Abstract: The genetically engineered chimeric antigen receptor T cell (CAR‐T) therapy has shown remarkable clinical efficacy in the treatment of hematological malignancies. Nonetheless, it is difficult to harvest adequate autologous T cells to manufacture potent CAR‐T cell products in patients with high tumor burden and prior tumor‐reductive treatment. Here we reported a relapsed/refractory acute lymphoblastic leukemia patient with high leukemia burden and central nervous system (CNS) involvement. The patient responded to donor‐derived HLA‐matched allogeneic CAR‐T treatment, with the achievement of quick complete remission. And for the first time, we revealed the development of a cerebral CRS in situ after allogeneic CAR‐T therapy.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
HLA‐matched allogeneic anti‐CD19 CAR‐T therapy in treating a relapsed/refractory acute lymphoblastic leukemia patient with high tumor burden ; day:27 ; month:03 ; year:2022 ; extent:6
ImmunoMedicine ; (27.03.2022) (gesamt 6)
- Urheber
-
Huang, Yue
Yu, Qin
Yin, Elaine Tan Su
Wei, Guoqing
Wu, Wenjun
Chang, Alex H.
Huang, He
Hu, Yongxian
- DOI
-
10.1002/imed.1032
- URN
-
urn:nbn:de:101:1-2022032815081697677546
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 07:22 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Huang, Yue
- Yu, Qin
- Yin, Elaine Tan Su
- Wei, Guoqing
- Wu, Wenjun
- Chang, Alex H.
- Huang, He
- Hu, Yongxian
Ähnliche Objekte (12)
Does A Child Quantity-Quality Trade-Off Exist? Evidence from the One-Child Policy in China
Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CAR-T therapy
Family Size and Children’s Education: Evidence from the One-Child Policy in China
CAR-T Cell Therapy: Advances in Kidney-Related Diseases
Job Satisfaction and Trade Union Membership in Germany
Job Satisfaction and Trade Union Membership in Germany
Suffering and prejudice: Do negative emotions predict immigration concerns?
Immigration and Crimes against Natives: The 2015 Refugee Crisis in Germany
How do new immigration flows affect existing immigrants? Evidence from the refugee crisis in Germany
Suffering and prejudice: Do negative emotions predict immigration concerns?
Suffering and prejudice: Do negative emotions predict immigration concerns?
Job Satisfaction and Trade Union Membership in Germany
Does A Child Quantity-Quality Trade-Off Exist? Evidence from the One-Child Policy in China
Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CAR-T therapy
Family Size and Children’s Education: Evidence from the One-Child Policy in China
CAR-T Cell Therapy: Advances in Kidney-Related Diseases
Job Satisfaction and Trade Union Membership in Germany
Job Satisfaction and Trade Union Membership in Germany
Suffering and prejudice: Do negative emotions predict immigration concerns?
Immigration and Crimes against Natives: The 2015 Refugee Crisis in Germany
How do new immigration flows affect existing immigrants? Evidence from the refugee crisis in Germany
Suffering and prejudice: Do negative emotions predict immigration concerns?
Suffering and prejudice: Do negative emotions predict immigration concerns?
Job Satisfaction and Trade Union Membership in Germany
Does A Child Quantity-Quality Trade-Off Exist? Evidence from the One-Child Policy in China
Humanized CD19 CAR-T cells in relapsed/refractory B-ALL patients who relapsed after or failed murine CD19 CAR-T therapy
Family Size and Children’s Education: Evidence from the One-Child Policy in China
CAR-T Cell Therapy: Advances in Kidney-Related Diseases
Job Satisfaction and Trade Union Membership in Germany
Job Satisfaction and Trade Union Membership in Germany
Suffering and prejudice: Do negative emotions predict immigration concerns?
Immigration and Crimes against Natives: The 2015 Refugee Crisis in Germany
How do new immigration flows affect existing immigrants? Evidence from the refugee crisis in Germany
Suffering and prejudice: Do negative emotions predict immigration concerns?
Suffering and prejudice: Do negative emotions predict immigration concerns?