Polypeptide‐ and Protein‐Based Conjugate Nanoparticles via Aqueous Ring‐Opening Polymerization‐Induced Self‐Assembly (ROPISA)

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Abstract: Protein–polymer conjugates and polymeric nanomaterials hold great promise in many applications including biomaterials, medicine, or nanoelectronics. In this work, the first polymerization‐induced self‐assembly (PISA) approach performed in aqueous medium enabling protein–polymer conjugates and nanoparticles entirely composed of amino acids is presented by using ring‐opening polymerization (ROP). It is indeed shown that aqueous ring‐opening polymerization‐induced self‐assembly (ROPISA) can be used with protein or peptidic macroinitiators without prior chemical modification and afford the simple preparation of nanomaterials with protein‐like property, for example, to implement biomimetic thermoresponsivity in drug delivery.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Polypeptide‐ and Protein‐Based Conjugate Nanoparticles via Aqueous Ring‐Opening Polymerization‐Induced Self‐Assembly (ROPISA) ; day:02 ; month:05 ; year:2024 ; extent:8
Macromolecular rapid communications ; (02.05.2024) (gesamt 8)

Urheber
Beauseroy, Hannah
Grazon, Chloe
Antoine, Segolene
Badreldin, Mostafa
Salas‐Ambrosio, Pedro
Harrisson, Simon
Garanger, Elisabeth
Lecommandoux, Sebastien
Bonduelle, Colin

DOI
10.1002/marc.202400079
URN
urn:nbn:de:101:1-2405031414500.985711028178
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:52 MESZ

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Beteiligte

  • Beauseroy, Hannah
  • Grazon, Chloe
  • Antoine, Segolene
  • Badreldin, Mostafa
  • Salas‐Ambrosio, Pedro
  • Harrisson, Simon
  • Garanger, Elisabeth
  • Lecommandoux, Sebastien
  • Bonduelle, Colin

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