Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets
Abstract: Swine influenza A viruses (swIAV) cause an economically important respiratory disease in modern pig production. Continuous virus transmission and antigenic drift are difficult to control in enzootically infected pig herds. Here, antibody-positive piglets from a herd enzootically infected with swIAV H1N2 (clade 1 A.3.3.2) were immunized using a homologous prime-boost vaccination strategy with novel live attenuated influenza virus (LAIV) based on a reassortment-incompetent bat influenza-swIAV chimera or a vesicular stomatitis virus-based replicon vaccine. Challenge infection of vaccinated piglets by exposure to H1N2 swIAV-infected unvaccinated seeder pigs showed that both LAIV and replicon vaccine markedly reduced virus replication in the upper and lower respiratory tract, respectively, compared to piglets immunized with commercial heterologous or autologous adjuvanted whole-inactivated virus vaccines. Our novel vaccines may aid in interrupting continuous IAV transmission chains in large enzootically infected pig herds, improve the health status of the animals, and reduce the risk of zoonotic swIAV transmission
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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npj vaccines. - 9, 1 (2024) , 127, ISSN: 2059-0105
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2024
- Creator
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Graaf-Rau, Annika
Schmies, Kathrin
Breithaupt, Angele
Ciminski, Kevin
Zimmer, Gert
Summerfield, Artur
Sehl-Ewert, Julia
Lillie-Jaschniski, Kathrin
Helmer, Carina
Bielenberg, Wiebke
Große Beilage, Elisabeth
Schwemmle, Martin
Beer, Martin
Harder, Timm C.
- DOI
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10.1038/s41541-024-00916-x
- URN
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urn:nbn:de:bsz:25-freidok-2555477
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:54 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Graaf-Rau, Annika
- Schmies, Kathrin
- Breithaupt, Angele
- Ciminski, Kevin
- Zimmer, Gert
- Summerfield, Artur
- Sehl-Ewert, Julia
- Lillie-Jaschniski, Kathrin
- Helmer, Carina
- Bielenberg, Wiebke
- Große Beilage, Elisabeth
- Schwemmle, Martin
- Beer, Martin
- Harder, Timm C.
- Universität
Time of origin
- 2024
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Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution
Bats reveal the true power of influenza A virus adaptability
Influenza A viruses and zoonotic events - are we creating our own reservoirs?
Adaptation von Influenza-A-Viren an den humanen Restriktionsfaktor MxA
Generation of an attenuated chimeric bat influenza A virus live-vaccine prototype
Human MxA is a potent interspecies barrier for the novel bat-derived influenza A-like virus H18N11
The influenza A virus genome packaging network - complex, flexible and yet unsolved
Unexpected functional divergence of bat influenza virus NS1 proteins
Bat influenza viruses: insights in the molecular biology and characterization of infectious viruses
Development of a chimeric bat influenza A virus as a live vaccine
Novel insights into bat influenza A viruses
Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets
Anti-influenza A virus restriction factors that shape the human species barrier and virus evolution
Bats reveal the true power of influenza A virus adaptability
Influenza A viruses and zoonotic events - are we creating our own reservoirs?
Adaptation von Influenza-A-Viren an den humanen Restriktionsfaktor MxA
Generation of an attenuated chimeric bat influenza A virus live-vaccine prototype
Human MxA is a potent interspecies barrier for the novel bat-derived influenza A-like virus H18N11
The influenza A virus genome packaging network - complex, flexible and yet unsolved