Enzyme- and Chemo-enzyme-Catalyzed Stereodivergent Synthesis
Abstract: Multiple stereoisomers can be found when a substance contains chiral carbons in its chemical structure. To obtain the desired stereoisomers, asymmetric synthesis was proposed in the 1970s and developed rapidly at the beginning of this century. Stereodivergent synthesis, an extension of asymmetric synthesis in organic synthesis with the hope to produce all stereoisomers of chiral substances in high conversion and selectivity, enriches the variety of available products and serves as a reference suggestion for the synthesis of their derivatives and other compounds. Since biocatalysis has outstanding advantages of economy, environmental friendliness, high efficiency, and reaction at mild conditions, the biocatalytic reaction is regarded as an efficient strategy to perform stereodivergent synthesis. Thus, in this review, we summarize the stereodivergent synthesis catalyzed by enzymes or chemo-enzymes in cases where a compound contains two or three chiral carbons, i.e., at most four or eight stereoisomers are present. The types of reactions, including reduction of substituent ketones, cyclization reactions, olefin addition, and nonredox transesterification reactions, are also discussed for the understanding of the progress and application of biocatalysis in stereodivergent synthesis.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Enzyme- and Chemo-enzyme-Catalyzed Stereodivergent Synthesis ; volume:04 ; number:03 ; year:2022 ; pages:e121-e135
Pharmaceutical fronts ; 04, Heft 03 (2022), e121-e135
- Contributor
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Lv, Jia-Xiang
Ding, Ya-Qi
Huang, Chen-Ming
Guo, Ling-Ling
Fang, Jia-Li
Jia, Xian
Zhang, Wen-He
You, Song
Qin, Bin
- DOI
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10.1055/s-0042-1755556
- URN
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urn:nbn:de:101:1-2022120111434528793169
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lv, Jia-Xiang
- Ding, Ya-Qi
- Huang, Chen-Ming
- Guo, Ling-Ling
- Fang, Jia-Li
- Jia, Xian
- Zhang, Wen-He
- You, Song
- Qin, Bin
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