Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review
Background: Early diagnosis of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) by monitoring heart rate characteristics (HRC) of preterm infants might reduce the risk of death and morbidities. We aimed to systematically assess the effects of HRC monitoring on death, LOS, and NEC. Methods: A systematic search was performed in MEDLINE, Embase, Cochrane Library, and Web of Science. Results: Fifteen papers were included in this review. Three of these papers reported results from the only identified randomized controlled trial (RCT). This RCT showed that HRC monitoring resulted in a small but significant reduction in mortality (absolute risk reduction 2.1% [95% confidence interval 0.01–4.14]) without any differences in neurodevelopmental impairment. The risk of bias was rated high due to performance and detection bias and failure to correct for multiple testing. Most diagnostic cohort studies showed high discriminating accuracy in predicting LOS but lacked sufficient quality and generalizability. No studies for the detection of NEC were identified. Conclusion: Supported by multiple observational cohort studies, the RCT identified in this systematic review showed that HRC monitoring as an early warning system for LOS might reduce the risk of death in preterm infants. However, methodological weaknesses and limited generalizability do not justify implementation of HRC in clinical care. A large international RCT is warranted.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review ; volume:120 ; number:5 ; year:2023 ; pages:548-557 ; extent:10
Neonatology ; 120, Heft 5 (2023), 548-557 (gesamt 10)
- Creator
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Koppens, Hugo J.
Onland, W.
Visser, Douwe H.
Denswil, Nerissa P.
van Kaam, Anton H.
Lutterman, Claire A.
- DOI
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10.1159/000531118
- URN
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urn:nbn:de:101:1-2023101200350088646166
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:56 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Koppens, Hugo J.
- Onland, W.
- Visser, Douwe H.
- Denswil, Nerissa P.
- van Kaam, Anton H.
- Lutterman, Claire A.
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Late-onset volvulus without malrotation in extremely preterm infants - a case-control-study
Late-onset neonatal sepsis in Suzhou, China
Risikofaktoren der Late-Onset Sepsis bei Frühgeborenen
Late-Onset Sepsis among Extremely Preterm Infants of 24–28 Weeks Gestation: An International Comparison in 10 High-Income Countries
Carboxyhemoglobin as biomarker of late-onset sepsis in preterm infants
Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis
Risk Factors for Late-Onset Sepsis in Preterm Infants: A Multicenter Case-Control Study
Intestinal metabolomics in premature infants with late-onset sepsis
Gut microbiota in preterm infants with late-onset sepsis and pneumonia: a pilot case-control study
Prognostic accuracy of Neonatal SOFA score versus SIRS criteria in preterm infants with late-onset sepsis
The association between clinical and biochemical characteristics of late-onset sepsis and bronchopulmonary dysplasia in preterm infants
Early and late onset sepsis in late preterm infants
Late-onset volvulus without malrotation in extremely preterm infants - a case-control-study
Late-onset neonatal sepsis in Suzhou, China
Risikofaktoren der Late-Onset Sepsis bei Frühgeborenen