Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions

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Abstract: Herein, we report on the discovery and development of novel cascade N−N bond forming reactions for the synthesis of rare indazole acetic acid scaffolds. This approach allows for convenient synthesis of three distinct indazole acetic acid derivatives (unsubstituted, hydroxy, and alkoxy) by heating 3‐amino‐3‐(2‐nitroaryl) propanoic acids with an appropriate nucleophile/solvent under basic conditions. The reaction tolerates a range of functional groups and electronic effects and, in total, 23 novel indazole acetic acids were synthesized and characterized. This work offers a valuable strategy for the synthesis of useful scaffolds for drug discovery programs.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions ; day:24 ; month:05 ; year:2023 ; extent:6
European journal of organic chemistry ; (24.05.2023) (gesamt 6)

Creator: Odell, Luke R.
Skillinghaug, Bobo
Matt, Christof
Wu, Peng
Koolmeister, Tobias
Desroses, Matthieu
Llona‐Minguez, Sabin
Wallner, Olov
Helleday, Thomas
Scobie, Martin

DOI: 10.1002/ejoc.202300291

URN: urn:nbn:de:101:1-2023052515050974942040

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:55 AM CEST

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Odell, Luke R.
Skillinghaug, Bobo
Matt, Christof
Wu, Peng
Koolmeister, Tobias
Desroses, Matthieu
Llona‐Minguez, Sabin
Wallner, Olov
Helleday, Thomas
Scobie, Martin

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Synthesis of Substituted Indazole Acetic Acids by N−N Bond Forming Reactions

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