Impact of Surface Functionality on Biodistribution of Gold Nanoparticles in Silkworms
To date, animal models are still indispensable for studying biodistribution and elimination of nanomaterials. However, the use of mammals for in vivo experiments faces various challenges including increasing regulatory hurdles and costs. This study aims to validate larvae of the domestic silkworm Bombyx mori as an alternative invertebrate model for preliminary in vivo research. Organ distribution and elimination of gold nanoparticles (AuNPs) are compared with four different surface functionalities in silkworms after systemic administration: AuNPs coated with poly (ethylene glycol) (PEG), with polyglycidols (PGs) that are slightly hydrophobic (PG (alkyl)), positively charged (PG (+)), or negatively charged (PG (−)). Subsequent inductive coupled plasma mass spectrometry 6 or 24 h after AuNPs administration reveals the biodistribution in silkworm hemolymph, midgut, epidermis, and excrements. Even after 24 h incubation, hemolymph contains the highest AuNPs concentrations, independent of surface functionalization indicating a prolonged circulation time and slow distribution into different silkworm organs and tissues. Positively charged PG (+) AuNPs show three times higher concentrations in the midgut and are excreted at the fastest rate when compared to other AuNPs. In the findings, a surface‐dependent biodistribution and elimination of AuNPs are indicated in silkworms, and the feasibility of using this inexpensive animal model for time‐ and cost‐effective, preliminary in vivo studies of NPs is confirmed.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Impact of Surface Functionality on Biodistribution of Gold Nanoparticles in Silkworms ; day:11 ; month:05 ; year:2024 ; extent:7
Advanced nanoBiomed research ; (11.05.2024) (gesamt 7)
- Creator
- DOI
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10.1002/anbr.202200146
- URN
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urn:nbn:de:101:1-2405121408079.983383007568
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:00 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lutz, Johanna
- Yu, Yidong
- Wolf, Ann‐Katrin
- Beilhack, Andreas
- Groll, Jürgen
- Albrecht, Krystyna
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