Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

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Abstract: The hydrazide 5, that was obtained from 1-(4-fluorophenyl) piperazine (1), was converted to the corresponding carbothioamides 6a–c by the reaction with alkyl (aryl) isothiocyanates. The synthesis of conazole analogs 10a–f was performed via the intermediary of triazoles 7a–c. The condensation of triazoles 7a–c with several heterocyclic amines in the presence of formaldehyde afforded the corresponding N-aminoalkylated triazoles 11–14. The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reactions was examined. The synthesized compounds were screened for their antimicrobial activities.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds ; volume:23 ; number:1 ; year:2017 ; pages:43-54 ; extent:12
Heterocyclic communications ; 23, Heft 1 (2017), 43-54 (gesamt 12)

Creator: Basoglu Ozdemir, Serap
Uygun Cebeci, Yıldız
Bayrak, Hacer
Mermer, Arif
Ceylan, Sule
Demirbas, Ahmet
Alpay Karaoglu, Sengul
Demirbas, Neslihan

DOI: 10.1515/hc-2016-0125

URN: urn:nbn:de:101:1-2501130612535.133063087185

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:27 AM CEST

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Basoglu Ozdemir, Serap
Uygun Cebeci, Yıldız
Bayrak, Hacer
Mermer, Arif
Ceylan, Sule
Demirbas, Ahmet
Alpay Karaoglu, Sengul
Demirbas, Neslihan

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Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

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