Nanocarriers Made of Proteins: Intracellular Visualization of a Smart Biodegradable Drug Delivery System

Abstract: This work analyzes the intracellular fate of protein‐based nanocarriers along their endolysosomal pathway by means of correlative light and electron microscopy methods. To unambiguously identify the nanocarriers and their degradation remnants in the cellular environment, they are labeled with fluorescent, inorganic nanoplatelets. This allows tracking the nanocarriers on their intracellular pathway by means of electron microscopy imaging. From the present data, it is possible to identify different cell compartments in which the nanocarriers are processed. Finally, three different terminal routes for the intracellular destiny of the nanocarriers are presented. These findings are important to reveal the degradation process of protein nanocapsules and contribute to the understanding of the therapeutic success of an encapsulated drug.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Nanocarriers Made of Proteins: Intracellular Visualization of a Smart Biodegradable Drug Delivery System ; day:27 ; month:02 ; year:2022 ; extent:8 ; Small ; (27.02.2022) (gesamt 8)

Beteiligte, Orts- und Zeitangaben

• Urheber: Frey, Marie‐Luise ; Han, Shen ; Halim, Henry ; Kaltbeitzel, Anke ; Riedinger, Andreas ; Landfester, Katharina ; Lieberwirth, Ingo

Weitere Informationen

• DOI: 10.1002/smll.202106094
• URN: urn:nbn:de:101:1-2022022814112375835611
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:29 MESZ