Multimodal Photoacoustic Imaging‐Guided Regression of Corneal Neovascularization: A Non‐Invasive and Safe Strategy
Abstract: Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. However, current medical treatments cannot achieve non‐invasive and safe inhibition of CNV. A noninvasive photoacoustic imaging (PAI)‐guided method is purposed for the regression of CNV. PAI can monitor the oxygen saturation of cornea blood vessels through the endogenous contrast of hemoglobin and trace administrated drugs by themselves as exogenous contrast agents. An indocyanine green (ICG)‐based nanocomposite (R‐s‐ICG) is prepared for CNV treatment via eye drops and subconjunctival injections. It is demonstrated that R‐s‐ICG can enrich corneal tissues and pathological blood vessels rapidly with minor residua in normal eyeball tissues. Anti‐CNV treatment‐driven changes in the blood vessels are assessed by real‐time multimodal PAI in vivo, and then a safe laser irradiation strategy through the canthus is developed for phototherapy and gene therapy synergistic treatment. The treatment leads to the efficient inhibition of CNV with faint damages to normal tissues.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Multimodal Photoacoustic Imaging‐Guided Regression of Corneal Neovascularization: A Non‐Invasive and Safe Strategy ; volume:7 ; number:14 ; year:2020 ; extent:7
Advanced science ; 7, Heft 14 (2020) (gesamt 7)
- Creator
-
Chu, Chengchao
Yu, Jingwen
Ren, En
Ou, Shangkun
Zhang, Yunming
Wu, Yiming
Wu, Han
Zhang, Yang
Zhu, Jing
Dai, Qixuan
Wang, Xiaoyong
Zhao, Qingliang
Li, Wei
Liu, Zuguo
Chen, Xiaoyuan
Liu, Gang
- DOI
-
10.1002/advs.202000346
- URN
-
urn:nbn:de:101:1-2022062410554568383932
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:20 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Chu, Chengchao
- Yu, Jingwen
- Ren, En
- Ou, Shangkun
- Zhang, Yunming
- Wu, Yiming
- Wu, Han
- Zhang, Yang
- Zhu, Jing
- Dai, Qixuan
- Wang, Xiaoyong
- Zhao, Qingliang
- Li, Wei
- Liu, Zuguo
- Chen, Xiaoyuan
- Liu, Gang
Other Objects (12)
Mental disorder or conscious disturbance in epidermal growth factor receptor-tyrosine kinase inhibitor treatment of advanced lung adenocarcinoma
The role of COX2 deficiency attenuates cardiac damage in acute myocardial infarction
Arsenic prepared by Chinese alchemist-pharmacists
Single event response of ferroelectric spacer engineered SOI FinFET at 14 nm technology node
A comparative study of percutaneous endoscopic interlaminar discectomy and transforaminal discectomy for L5-S1 calcified lumbar disc herniation
Using LMDI approach to analyze changes in carbon dioxide emissions of China's logistics industry
Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches
Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AHCP−3 Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes
Cellular senescence in Alzheimer’s disease: from physiology to pathology
Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies
Random Raman Fiber Laser as a Liquid Refractive Index Sensor
Dynamic responses of a train-track-bridge coupled system under earthquakes
Mental disorder or conscious disturbance in epidermal growth factor receptor-tyrosine kinase inhibitor treatment of advanced lung adenocarcinoma
The role of COX2 deficiency attenuates cardiac damage in acute myocardial infarction
Arsenic prepared by Chinese alchemist-pharmacists
Single event response of ferroelectric spacer engineered SOI FinFET at 14 nm technology node
A comparative study of percutaneous endoscopic interlaminar discectomy and transforaminal discectomy for L5-S1 calcified lumbar disc herniation
Using LMDI approach to analyze changes in carbon dioxide emissions of China's logistics industry
Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches
Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AHCP−3 Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes
Cellular senescence in Alzheimer’s disease: from physiology to pathology
Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies
Random Raman Fiber Laser as a Liquid Refractive Index Sensor
Dynamic responses of a train-track-bridge coupled system under earthquakes
Mental disorder or conscious disturbance in epidermal growth factor receptor-tyrosine kinase inhibitor treatment of advanced lung adenocarcinoma
The role of COX2 deficiency attenuates cardiac damage in acute myocardial infarction
Arsenic prepared by Chinese alchemist-pharmacists
Single event response of ferroelectric spacer engineered SOI FinFET at 14 nm technology node
A comparative study of percutaneous endoscopic interlaminar discectomy and transforaminal discectomy for L5-S1 calcified lumbar disc herniation
Using LMDI approach to analyze changes in carbon dioxide emissions of China's logistics industry
Comprehensive Proteoform Characterization of Plasma Complement Component C8αβγ by Hybrid Mass Spectrometry Approaches
Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AHCP−3 Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes
Cellular senescence in Alzheimer’s disease: from physiology to pathology
Unraveling molecular signatures and prognostic biomarkers in glioblastoma: a comprehensive study on treatment resistance and personalized strategies
Random Raman Fiber Laser as a Liquid Refractive Index Sensor