Electrospun coaxial hyaluronan-based fiber networks for ophthalmic drug release
Abstract: A micro-sized core-shell drug release device has been prepared by coaxial electrospinning based on a polylactide shell and the inner core phase made of high molecular weight hyaluronan or a cross-linked hyaluronan network. Timolol, which was inserted into the core phase, is widely used as drug for glaucoma treatment to depress the intraocular eye pressure and should be released over a longer time period from this fiber networks. Release studies of drug loaded fiber devices showed an only moderate burst release of timolol in the first days followed by a continuous longlasting drug release period over several weeks. With these findings, coaxial electrospinning represents a promising approach for the development of drug release systems with long-lasting, relatively constant drug delivery.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Electrospun coaxial hyaluronan-based fiber networks for ophthalmic drug release ; volume:7 ; number:2 ; year:2021 ; pages:688-691 ; extent:4
Current directions in biomedical engineering ; 7, Heft 2 (2021), 688-691 (gesamt 4)
- Urheber
-
Walter, Torsten
Wyrwa, Ralf
Altmann, Cindy
Schnabelrauch, Matthias
- DOI
-
10.1515/cdbme-2021-2175
- URN
-
urn:nbn:de:101:1-2022101214124485171599
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:31 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Walter, Torsten
- Wyrwa, Ralf
- Altmann, Cindy
- Schnabelrauch, Matthias
Ähnliche Objekte (12)
A novel coaxial nozzle for in-process adjustment of electrospun scaffolds’ fiber diameter : Electrospun mats and their dependence on process parameters
Elastin‐Hyaluronan Bioconjugate as Bioactive Component in Electrospun Scaffolds
Fiber composite materials via coaxial, dual or blend electrospinning
Electrospun Polymer Fiber Systems for Flexible Electronics
Preparation and Properties of Electrospun Polyacrylonitrile Fiber Assemblies
Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering
Approach to Obtain Electrospun Hydrophilic Fibers and Prevent Fiber Necking
Approach to Obtain Electrospun Hydrophilic Fibers and Prevent Fiber Necking
Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer
Electrospun fibrous sponge via short fiber for mimicking 3D ECM
Enhanced viability of Lactobacillus spp. via encapsulation in hyaluronan/PVA hybrid electrospun composites for vaginal drug delivery
On coaxial circles.
A novel coaxial nozzle for in-process adjustment of electrospun scaffolds’ fiber diameter : Electrospun mats and their dependence on process parameters
Elastin‐Hyaluronan Bioconjugate as Bioactive Component in Electrospun Scaffolds
Fiber composite materials via coaxial, dual or blend electrospinning
Electrospun Polymer Fiber Systems for Flexible Electronics
Preparation and Properties of Electrospun Polyacrylonitrile Fiber Assemblies
Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering
Approach to Obtain Electrospun Hydrophilic Fibers and Prevent Fiber Necking
Approach to Obtain Electrospun Hydrophilic Fibers and Prevent Fiber Necking
Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer
Electrospun fibrous sponge via short fiber for mimicking 3D ECM
Enhanced viability of Lactobacillus spp. via encapsulation in hyaluronan/PVA hybrid electrospun composites for vaginal drug delivery
On coaxial circles.
A novel coaxial nozzle for in-process adjustment of electrospun scaffolds’ fiber diameter : Electrospun mats and their dependence on process parameters
Elastin‐Hyaluronan Bioconjugate as Bioactive Component in Electrospun Scaffolds
Fiber composite materials via coaxial, dual or blend electrospinning
Electrospun Polymer Fiber Systems for Flexible Electronics
Preparation and Properties of Electrospun Polyacrylonitrile Fiber Assemblies
Mueller Matrix Measurement of Electrospun Fiber Scaffolds for Tissue Engineering
Approach to Obtain Electrospun Hydrophilic Fibers and Prevent Fiber Necking
Approach to Obtain Electrospun Hydrophilic Fibers and Prevent Fiber Necking
Electrospun silk-based nanofibrous scaffolds: fiber diameter and oxygen transfer
Electrospun fibrous sponge via short fiber for mimicking 3D ECM
Enhanced viability of Lactobacillus spp. via encapsulation in hyaluronan/PVA hybrid electrospun composites for vaginal drug delivery