Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells
Abstract: Most of advanced hypopharyngeal squamous cell carcinoma (HSCC) are resistant to chemotherapy, and there is still lack of effective treatment for HSCC now. The present study aimed to investigate whether downregulation of RNA-binding motif protein 17 (RBM17) could enhance cisplatin sensitivity and inhibit cell invasion in HSCC and the underlying mechanism. We observed that RBM17 was upregulated in tumor tissues and associated with poor progression. Treatment of FaDu cells with cisplatin increased RBM17 expression in mRNA levels. Downregulation of RBM17 enhanced cisplatin-mediated inhibition of FaDu cells. In addition, downregulation of RBM17 effectively suppressed tumor cell migration and invasion through the reversion of epithelial–mesenchymal transition. Moreover, downregulation of RBM17 could significantly slow tumor growth in FaDu xenograft tumor model. Liquid chromatography–mass spectrometry/mass spectrometry detection and independent PRM analysis showed that 21 differentially expressed proteins were associated with the downregulation of RBM17. Taken together, our study implied that downregulation of RBM17 could serve as a novel approach to enhance cisplatin sensitivity in HSCC.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Downregulation of RBM17 enhances cisplatin sensitivity and inhibits cell invasion in human hypopharyngeal cancer cells ; volume:18 ; number:1 ; year:2023 ; extent:12
Open medicine ; 18, Heft 1 (2023) (gesamt 12)
- Creator
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Wang, Xiaolin
Chen, Deshang
Han, Guoying
Wang, Xiaomin
Liu, Xuebao
Xu, Binbin
Liu, Weiwei
Li, Hui
Zhang, Mingjie
Ma, Shiyin
Han, Yuefeng
- DOI
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10.1515/med-2023-0669
- URN
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urn:nbn:de:101:1-2023031513522728852765
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:59 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wang, Xiaolin
- Chen, Deshang
- Han, Guoying
- Wang, Xiaomin
- Liu, Xuebao
- Xu, Binbin
- Liu, Weiwei
- Li, Hui
- Zhang, Mingjie
- Ma, Shiyin
- Han, Yuefeng
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