Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications

Abstract: Recognition of the molecular basis of gastrointestinal stromal tumors has paved the way for significant breakthroughs in the diagnosis and treatment of this disease as well as positioned gastrointestinal stromal tumors as a framework for the concept of precision oncology in solid tumors. The incorporation of novel targeted agents for molecularly defined subgroups has led to significant improvements in treatment outcomes; however, the characterization of heterogeneous KIT or PDGFRA mutations and the emergence of resistance mechanisms highlight the need for a broader use of comprehensive molecular profiling and emphasize the importance of molecularly driven adaptive treatment strategies. Such a molecular background is critical for developing personalized and effective interventions and optimizing outcomes. The present review summarizes key studies that provide the basis for standard-of-care management options as well as provides molecular insights into the management of gastrointestinal stromal tumors, with an emphasis on recent advances.

Object Details

• Alternative title: Tumores estromais gastrointestinais: avanços na caracterização molecular e implicações terapêuticas
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Gastrointestinal stromal tumors: advances in molecular characterization and therapeutic implications ; volume:20 ; number:CP ; year:2024 ; Brazilian journal of oncology ; 20, Heft CP (2024)

Contributors, Places and Time

• Contributor: Lima, Nildevande Firmino ; Queiroz, Marcello Moro ; Leal Franco, Julia Sousa ; Lins, Julia Sousa ; de Campos, Eduardo Felício ; Awni, Beatriz Mendes ; Aureliano de Lima, Luiz Guilherme Cernaglia ; Teixeira, Frederico ; Ferreira, Fábio de Oliveira ; Akaishi, Eduardo Hiroshi ; Capareli, Fernanda Cunha ; Munhoz, Rodrigo Ramella

Further information

• DOI: 10.5935/2526-8732.20240468
• URN: urn:nbn:de:101:1-2501301155293.820271353383
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:30 AM CEST