Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin

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Abstract: Multifunctional porphyrin–peptide conjugates with different propensities for self‐assembly into various supramolecular nanoarchitectures play important roles in advanced materials and biomedical research. However, preparing prefunctionalized core porphyrins by traditional low‐yielding statistical synthesis and purifying them after peptide ligation through many rounds of HPLC purification is tedious and unsustainable. Herein, we report a novel integrated solid‐phase synthetic protocol for the construction of porphyrin moieties from simple aldehydes and dipyrromethanes on resin‐bound peptides directly to form mono‐, cis/trans‐di‐, and trivalent porphyrin–peptide conjugates in a highly efficient and controllable manner; moreover, only single final‐stage HPLC purification of the products is needed. This efficient strategy enables the rapid, greener, and substrate‐controlled diversity‐oriented synthesis of multivalent porphyrin–(long) peptide conjugate libraries for multifarious biological and materials applications.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin ; day:11 ; month:07 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (11.07.2022) (gesamt 1)

Creator: Wu, Yue
Chau, Ho‐Fai
Yeung, Yik‐Hoi
Thor, Waygen
Kai, Hei‐Yui
Chan, Wai‐Lun
Wong, Ka‐Leung

DOI: 10.1002/anie.202207532

URN: urn:nbn:de:101:1-2022071215090402113712

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:25 AM CEST

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Wu, Yue
Chau, Ho‐Fai
Yeung, Yik‐Hoi
Thor, Waygen
Kai, Hei‐Yui
Chan, Wai‐Lun
Wong, Ka‐Leung

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