Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin
Abstract: Multifunctional porphyrin–peptide conjugates with different propensities for self‐assembly into various supramolecular nanoarchitectures play important roles in advanced materials and biomedical research. However, preparing prefunctionalized core porphyrins by traditional low‐yielding statistical synthesis and purifying them after peptide ligation through many rounds of HPLC purification is tedious and unsustainable. Herein, we report a novel integrated solid‐phase synthetic protocol for the construction of porphyrin moieties from simple aldehydes and dipyrromethanes on resin‐bound peptides directly to form mono‐, cis/trans‐di‐, and trivalent porphyrin–peptide conjugates in a highly efficient and controllable manner; moreover, only single final‐stage HPLC purification of the products is needed. This efficient strategy enables the rapid, greener, and substrate‐controlled diversity‐oriented synthesis of multivalent porphyrin–(long) peptide conjugate libraries for multifarious biological and materials applications.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin ; day:11 ; month:07 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (11.07.2022) (gesamt 1)
- Urheber
-
Wu, Yue
Chau, Ho‐Fai
Yeung, Yik‐Hoi
Thor, Waygen
Kai, Hei‐Yui
Chan, Wai‐Lun
Wong, Ka‐Leung
- DOI
-
10.1002/anie.202207532
- URN
-
urn:nbn:de:101:1-2022071215090402113712
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 07:25 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Wu, Yue
- Chau, Ho‐Fai
- Yeung, Yik‐Hoi
- Thor, Waygen
- Kai, Hei‐Yui
- Chan, Wai‐Lun
- Wong, Ka‐Leung
Ähnliche Objekte (12)
Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin
Peptide Multifunctionalization via Modular Construction of Trans ‐AB 2 C Porphyrin on Resin
Manifold‐Fused Porphyrin‐Nanographene Conjugates
Manifold‐Fused Porphyrin‐Nanographene Conjugates
Backward Euler–Maruyama Method for the Random Periodic Solution of a Stochastic Differential Equation with a Monotone Drift
From porphyrin benzylphosphoramidate conjugates to the catalytic hydrogenation of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Direct Construction of Corrole‐Peptide Conjugates by Controllable Bilane Formation on Resin
Porphyrin-Isomere
Supramolecular fullerene-porphyrin architectures : = Supramolekulare Fulleren-Porphyrin-Architekturen
Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin
Peptide Multifunctionalization via Modular Construction of Trans ‐AB 2 C Porphyrin on Resin
Manifold‐Fused Porphyrin‐Nanographene Conjugates
Manifold‐Fused Porphyrin‐Nanographene Conjugates
Backward Euler–Maruyama Method for the Random Periodic Solution of a Stochastic Differential Equation with a Monotone Drift
From porphyrin benzylphosphoramidate conjugates to the catalytic hydrogenation of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Direct Construction of Corrole‐Peptide Conjugates by Controllable Bilane Formation on Resin
Porphyrin-Isomere
Supramolecular fullerene-porphyrin architectures : = Supramolekulare Fulleren-Porphyrin-Architekturen
Versatile Synthesis of Multivalent Porphyrin–Peptide Conjugates by Direct Porphyrin Construction on Resin
Peptide Multifunctionalization via Modular Construction of Trans ‐AB 2 C Porphyrin on Resin
Manifold‐Fused Porphyrin‐Nanographene Conjugates
Manifold‐Fused Porphyrin‐Nanographene Conjugates
Backward Euler–Maruyama Method for the Random Periodic Solution of a Stochastic Differential Equation with a Monotone Drift
From porphyrin benzylphosphoramidate conjugates to the catalytic hydrogenation of 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Fused Hexabenzocoronene‐Porphyrin Conjugates with Tailorable Excited‐State Lifetimes
Direct Construction of Corrole‐Peptide Conjugates by Controllable Bilane Formation on Resin
Porphyrin-Isomere