Deciphering the Biological Activities of Antifungal Agents with Chemical Probes
Abstract: The growing number of fungal infections caused by pathogens resistant to one or more classes of antifungal drugs emphasizes the threat that these microorganisms pose to animal and human health and global food security. Open questions remain regarding the mechanisms of action of the limited repertoire of antifungal agents, making it challenging to rationally develop more efficacious therapeutics. In recent years, the use of chemical biology approaches has resolved some of these questions and has provided new promising concepts to guide the design of antifungal agents. By focusing on examples from studies carried out in recent years, this minireview describes the key roles that probes based on antifungal agents and their derivatives have played in uncovering details about their activities, in detecting resistance, and in characterizing the interactions between these agents and their targets.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Deciphering the Biological Activities of Antifungal Agents with Chemical Probes ; day:26 ; month:01 ; year:2023 ; extent:11
Angewandte Chemie ; (26.01.2023) (gesamt 11)
- Urheber
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Fridman, Micha
Sakurai, Kaori
- DOI
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10.1002/ange.202211927
- URN
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urn:nbn:de:101:1-2023012714080180818899
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:24 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Fridman, Micha
- Sakurai, Kaori
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