Zebrafish dark-dependent behavior requires phototransduction by the pineal gland
Abstract: Located dorsally underneath a thin translucent skull in many teleosts, the pineal gland is a photoreceptive organ known as a key element of the circadian clock system. Nevertheless, the presence of additional routes of photoreception presents a challenge in determining its specific roles in regulating photic-related behavior. Here, we show the importance of the pineal gland in mediating a prolonged motor response of zebrafish larvae to sudden darkness, both as a photodetector and as a circadian pacemaker. This was evident by a reduced motor response of Bsx-deficient larvae, lacking a pineal gland, to sudden darkness. Moreover, the typical daily rhythm of the intensity of this response was lost in the pineal-less larvae. In contrast, motor response to a sudden increase in illumination was unaffected. Furthermore, we show that the pineal-mediated behavioral response to darkness requires two elements: the photoreceptor cells and the projecting neurons. Dark response was impaired in larvae whose pineal photoreceptor cells were genetically ablated and in larvae whose pineal projecting neurons had undergone laser-axotomy. This study thus establishes the pineal gland as a mediator of dark-dependent behavior and reveals underlying cellular components involved in transducing information about darkness to the brain
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Journal of pineal research. - 76, 8 (2024) , e70021, ISSN: 1600-079X
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2025
- Creator
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Wexler, Yair
Huang, Dengfeng
Medvetzky, Adar
Armbruster, Daniel
Driever, Wolfgang
Yan, Jun
Gothilf, Yoav
- DOI
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10.1111/jpi.70021
- URN
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urn:nbn:de:bsz:25-freidok-2621786
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:26 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Wexler, Yair
- Huang, Dengfeng
- Medvetzky, Adar
- Armbruster, Daniel
- Driever, Wolfgang
- Yan, Jun
- Gothilf, Yoav
- Universität
Time of origin
- 2025
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