Gap43 transcription modulation in the adult brain depends on sensory activity and synaptic cooperation
Abstract: Brain development and learning is accompanied by morphological and molecular changes in neurons. The growth associated protein 43 (Gap43), indicator of neurite elongation and synapse formation, is highly expressed during early stages of development. Upon maturation of the brain, Gap43 is down-regulated by most neurons with the exception of subdivisions such as the CA3 region of hippocampus, the lateral superior olive (LSO) and the central inferior colliculus (CIC). Little is known about the regulation of this mRNA in adult brains. We found that the expression of Gap43 mRNA in specific neurons can be modulated by changing sensory activity of the adult brain. Using the central auditory system of rats as a model, Gap43 protein and mRNA levels were determined in LSO and CIC of hearing-experienced rats unilaterally or bilaterally deafened or unilaterally stimulated by a cochlear implant (CI). Our data indicate that Gap43 is a marker useful beyond monitoring neuronal growth and synaptogenesis, reflecting also specific patterns of synaptic activities on specific neurons. Thus, unilateral loss of input to an adult auditory system directly causes asymmetrical expression of Gap43 mRNA between LSOs or CICs on both sides of the brainstem. This consequence can be prevented by simple-patterned stimulation of a dysfunctional ear by way of a CI. We suggest that as a function of input balance and activity pattern, Gap43 mRNA expression changes as cells associate converging afferent signals
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
PLoS ONE. 9, 3 (2014), e92624, DOI 10.1371/journal.pone.0092624, issn: 1932-6203
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
- Schlagwort
-
Hirnstamm
Ohr
Genexpression
Cochlea
Gehörlosigkeit
Ohrenkrankheit
Audiologie
Ohrenheilkunde
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2014
- Urheber
- Beteiligte Personen und Organisationen
-
Neurobiologisches Forschungslabor
Albert-Ludwigs-Universität Freiburg
Medizinische Fakultät
- DOI
-
10.1371/journal.pone.0092624
- URN
-
urn:nbn:de:bsz:25-freidok-120255
- Rechteinformation
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:55 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Roßkothen-Kuhl, Nicole
- Illing, Robert-Benjamin
- Neurobiologisches Forschungslabor
- Albert-Ludwigs-Universität Freiburg
- Medizinische Fakultät
- Universität
Entstanden
- 2014
Ähnliche Objekte (12)
Sensory hair cells : synaptic transmission
Perceptual learning of task-irrelevant features depends on the sensory context
Synaptic interactions in the rodent thalamocortical system during sensory
Synaptic and circuit development of the primary sensory cortex
Sensory integration by hippocampal synaptic plasticity and place cells
Sensory information processing in hippocampal synaptic plasticity, spatial and extinction learning
The influence of cortical activity on perception depends on behavioral state and sensory context
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
That Depends
Co-evolution of transcription factors and their targets depends on mode of regulation
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
The mechanisms underlying synaptic transmission at the layer 4 of sensory cortical areas
Sensory hair cells : synaptic transmission
Perceptual learning of task-irrelevant features depends on the sensory context
Synaptic interactions in the rodent thalamocortical system during sensory
Synaptic and circuit development of the primary sensory cortex
Sensory integration by hippocampal synaptic plasticity and place cells
Sensory information processing in hippocampal synaptic plasticity, spatial and extinction learning
The influence of cortical activity on perception depends on behavioral state and sensory context
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
That Depends
Co-evolution of transcription factors and their targets depends on mode of regulation
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB
The mechanisms underlying synaptic transmission at the layer 4 of sensory cortical areas
Sensory hair cells : synaptic transmission
Perceptual learning of task-irrelevant features depends on the sensory context
Synaptic interactions in the rodent thalamocortical system during sensory
Synaptic and circuit development of the primary sensory cortex
Sensory integration by hippocampal synaptic plasticity and place cells
Sensory information processing in hippocampal synaptic plasticity, spatial and extinction learning
The influence of cortical activity on perception depends on behavioral state and sensory context
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
That Depends
Co-evolution of transcription factors and their targets depends on mode of regulation
Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB