Imidazole Backbone Functionalization with Olefin Cross‐Metathesis
Abstract: A selective and high‐rate Ru‐catalyzed cross‐metathesis reaction of alkenes with vinylimidazole is disclosed. Cross‐metathesis is known to operate less efficiently on N‐heterocycles, but through optimization by means of statistical experimental design and multiple regression, optimal reaction conditions were identified that allowed for consistent high‐yields without the need of overly complicated set‐ups or additives. The method was tested on a series of terminal alkene reagents with a variety of different functional groups and it provides the corresponding target molecules in good to high yields.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Imidazole Backbone Functionalization with Olefin Cross‐Metathesis ; volume:2022 ; number:22 ; year:2022 ; extent:11
European journal of organic chemistry ; 2022, Heft 22 (2022) (gesamt 11)
- Urheber
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Angelucci, Francesco
Cirillo, Davide
Bjørsvik, Hans‐René
- DOI
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10.1002/ejoc.202200437
- URN
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urn:nbn:de:101:1-2022060915024889073125
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:30 MESZ
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Beteiligte
- Angelucci, Francesco
- Cirillo, Davide
- Bjørsvik, Hans‐René
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