A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles
Abstract: Synthetic macrocycles are an attractive area in drug discovery. However, their use has been hindered by a lack of versatile platforms for the generation of structurally (and thus shape) diverse macrocycle libraries. Herein, we describe a new concept in library synthesis, termed multidimensional diversity‐oriented synthesis, and its application towards macrocycles. This enabled the step‐efficient generation of a library of 45 novel, structurally diverse, and highly‐functionalized macrocycles based around a broad range of scaffolds and incorporating a wide variety of biologically relevant structural motifs. The synthesis strategy exploited the diverse reactivity of aza‐ylides and imines, and featured eight different macrocyclization methods, two of which were novel. Computational analyses reveal a broad coverage of molecular shape space by the library and provides insight into how the various diversity‐generating steps of the synthesis strategy impact on molecular shape.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles ; volume:128 ; number:37 ; year:2016 ; pages:11305-11309 ; extent:5
Angewandte Chemie ; 128, Heft 37 (2016), 11305-11309 (gesamt 5)
- Creator
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Nie, Feilin
Kunciw, Dominique L.
Wilcke, David
Stokes, Jamie E.
Galloway, Warren R. J. D.
Bartlett, Sean
Sore, Hannah F.
Spring, David R.
- DOI
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10.1002/ange.201605460
- URN
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urn:nbn:de:101:1-2022103004535891194794
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:32 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Nie, Feilin
- Kunciw, Dominique L.
- Wilcke, David
- Stokes, Jamie E.
- Galloway, Warren R. J. D.
- Bartlett, Sean
- Sore, Hannah F.
- Spring, David R.
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