Simple prediction model for unfavorable outcome in ischemic stroke after intravenous thrombolytic therapy

Objective: We aimed to develop a model to predict unfavorable outcome in patients with acute ischemic stroke treated with intravenous thrombolytic therapy (IVT), based on simple variables present on admission. Methods: Retrospective analysis of acute ischemic stroke patients treated with IVT in a hospital in Rio de Janeiro. Clinical and radiographic variables were selected for analysis. Multivariate logistic regression was used to develop a predictive model. Results: We analyzed a total of 82 patients. Median National Institutes of Health Stroke Scale (NIHSS) on admission was 9 (3–22), 40.2% presented with a hyperdense artery sign (HAS), 62% had identifiable early parenchymal changes and 61.6% experienced a favorable outcome. An NIHSS score of > 12 on arrival, age > 70 and the presence of HAS were associated with the outcome, even after correction in a logistic regression model. Conclusion: An NIHSS > 12 on arrival, presence of HAS and age > 70 years were predictors of unfavorable outcome at three months in patients with acute ischemic stroke treated with IVT.

Object Details

• Alternative title: Modelo simples de predição de desfecho desfavorável em acidente vascular cerebral isquêmico tratado após terapia trombolítica intravenosa
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Simple prediction model for unfavorable outcome in ischemic stroke after intravenous thrombolytic therapy ; volume:74 ; number:12 ; year:2016 ; pages:986-989 ; Arquivos de neuro-psiquiatria ; 74, Heft 12 (2016), 986-989

Contributors, Places and Time

• Contributor: Amitrano, Daniel ; Silva, Ivan Rocha Ferreira da ; Liberato, Bernardo B. ; Batistella, Valéria ; Oliveira, Janaina ; Nascimento, Osvaldo J. M.

Further information

• DOI: 10.1590/0004-282X20160152
• URN: urn:nbn:de:101:1-2023101912465181037889
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 11:00 AM CEST