Exposition of antitumour activity of a chemically characterized exopolysaccharide from a probiotic Lactobacillus plantarum MTCC 9510
Abstract: As majority of chemical compounds identified as anti-cancerous are toxic to normal cells, the discovery and identification of new safe drugs is a necessity in the biomedical field. The antioxidant, antitumour and immunomodulating properties of an exopolysaccharide of sequence -α-d-glucose, α-d-mannose and β-d-glucose-, purified from a probiotic Lactobacillus plantarum was studied. The immunostimulation of the compound in human lymphocytes was seen at a concentration of 0.1 mg/mL with 20% proliferation rate. The antitumour studies by morphological apoptosis determination and 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay on breast adenocarcinoma cell line (MCF-7) exhibited an IC50 of 10 mg/mL for the compound.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Exposition of antitumour activity of a chemically characterized exopolysaccharide from a probiotic Lactobacillus plantarum MTCC 9510 ; volume:68 ; number:6 ; year:2013 ; pages:1041-1047 ; extent:7
Biologia ; 68, Heft 6 (2013), 1041-1047 (gesamt 7)
- Creator
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Ismail, Bindhumol
Nampoothiri, Kesavan
- DOI
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10.2478/s11756-013-0275-2
- URN
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urn:nbn:de:101:1-2409231633343.984062231825
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:33 AM CEST
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Associated
- Ismail, Bindhumol
- Nampoothiri, Kesavan
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