The bovine dialyzable leukocyte extract, immunepotent CRP, synergically enhances cyclophosphamide-induced breast cancer cell death, through a caspase-independent mechanism
Abstract: Breast cancer (BC) is one of the leading causes of cancer death worldwide. Cyclophosphamide (CTX) remains a mainstay in cancer therapy despite harmful adverse effects and cell death-resistances. To face this, combinational therapy of chemotherapies and immunotherapies has been proposed. IMMUNEPOTENT CRP (ICRP) is an immunotherapy that has cytotoxic effects in several cancer cells without affecting peripheral blood mononuclear cells (PBMC) and CD3+ cells. The aim of this study was to evaluate cytotoxicity, the type of cytotoxic effect, and several features involved in cell death induced by the combination of CTX with ICRP (ICRP+CTX) in breast cancer cells as well as their effect on healthy cells. For this purpose, human and murine breast cancer cells, MCF-7, MDA-MB-231 and 4T1, or PBMC were treated for 24 hours with ICRP, CTX or ICRP+CTX in different combination ratios for the assessment of cell death. Flow cytometry and microscopy were used to determine biochemical and morphologica.... https://www.excli.de/index.php/excli/article/view/5389
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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The bovine dialyzable leukocyte extract, immunepotent CRP, synergically enhances cyclophosphamide-induced breast cancer cell death, through a caspase-independent mechanism ; volume:22 ; year:2023
EXCLI journal ; 22 (2023)
- Urheber
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Rivera-Lazarín, Ana Luisa
Martinez-Torres, Ana Carolina
de la Hoz-Camacho, Rafael
Guzmán-Aguillón, Olga Liliana
Franco-Molina, Moisés Armides
Rodríguez-Padilla, Cristina
- DOI
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10.17179/excli2022-5389
- URN
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urn:nbn:de:101:1-2023012702141394400861
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:20 MESZ
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Beteiligte
- Rivera-Lazarín, Ana Luisa
- Martinez-Torres, Ana Carolina
- de la Hoz-Camacho, Rafael
- Guzmán-Aguillón, Olga Liliana
- Franco-Molina, Moisés Armides
- Rodríguez-Padilla, Cristina
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