Molecular Engineering of Amino Acid Crystals with Enhanced Piezoelectric Performance for Biodegradable Sensors
Abstract: Amino acid crystals have emerged as promising piezoelectric materials for biodegradable and biocompatible sensors; however, their relatively low piezoelectric coefficients constrain practical applications. Here, we introduce a fluoro‐substitution strategy to overcome this limitation and enhance the piezoelectric performance of amino acid crystals. Specifically, we substituted hydrogen atoms on the aromatic rings of L‐tryptophan, L‐phenylalanine, and N‐Cbz‐L‐phenylalanine with fluorine, resulting in significantly elevated piezoelectric coefficients. Density functional theory calculations further indicate that fluorination strengthens polarization by modifying molecular dipole moments. Consequently, these fluoro‐substituted crystals achieve piezoelectric coefficients of up to 50.36 pm/V, surpassing those of other organic piezoelectric materials such as polyvinylidene fluoride (PVDF), poly (L‐lactic acid) (PLLA), and gelatin. When integrated into flexible, biodegradable force sensors, the fluoro‐substituted crystals exhibit a broad sensing range, high sensitivity, and stable in vivo operation over extended periods. This work establishes a versatile route for boosting piezoelectricity in biomaterials, thereby broadening their scope in biomedical applications.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Molecular Engineering of Amino Acid Crystals with Enhanced Piezoelectric Performance for Biodegradable Sensors ; day:03 ; month:02 ; year:2025 ; extent:11
Angewandte Chemie ; (03.02.2025) (gesamt 11)
- Creator
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Cheng, Yuanqi
Wang, Tianjian
Zhu, Haoqi
Hu, Xueli
Mi, Jing
Li, Lan
Zhang, Yu
Yang, Jiapeng
Dong, Liang
Li, Ying
Sun, Wenxu
Lu, Xiaomei
Wang, Wei
Cao, Yi
Xue, Bin
- DOI
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10.1002/ange.202500334
- URN
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urn:nbn:de:101:1-2502041313570.130260957406
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:28 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cheng, Yuanqi
- Wang, Tianjian
- Zhu, Haoqi
- Hu, Xueli
- Mi, Jing
- Li, Lan
- Zhang, Yu
- Yang, Jiapeng
- Dong, Liang
- Li, Ying
- Sun, Wenxu
- Lu, Xiaomei
- Wang, Wei
- Cao, Yi
- Xue, Bin
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Association between thymic hyperplasia and serum calcium level in Graves’ disease
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High‐Performance AgSbTe 2 Thermoelectrics: Advances, Challenges, and Perspectives
Argonaute proteins: potential biomarkers for human colon cancer
Impacts of family household dynamics on residential energy demands in Hebei Province of China
Molecular Engineering of Amino Acid Crystals with Enhanced Piezoelectric Performance for Biodegradable Sensors
Boosting the Piezoelectric Sensitivity of Amino Acid Crystals by Mechanical Annealing for the Engineering of Fully Degradable Force Sensors
Association between thymic hyperplasia and serum calcium level in Graves’ disease
Protecting Endangered Languages: The Case of Irish
RNA-TVcurve: a Web server for RNA secondary structure comparison based on a multi-scale similarity of its triple vector curve representation
The violent ground motion before the Jiuzhaigou earthquake Ms7.0
The impacts of marine-emitted halogens on OH radical in East Asia during summer
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The role of remote ischemic preconditioning on postoperative kidney injury in patients undergoing cardiac and vascular interventions: a meta-analysis
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Argonaute proteins: potential biomarkers for human colon cancer