Protein Nanoparticles for Targeted SARS‐CoV‐2 Trapping and Neutralization

Abstract: The coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to challenge global health despite widespread vaccination efforts, underscoring the need for innovative strategies to combat emerging infectious diseases effectively. Herein, LCB1‐NPs and LCB3‐NPs are engineered as a novel class of protein‐only nanoparticles formed through coiled coil‐driven self‐assembly and tailored to interact specifically with the SARS‐CoV‐2 spike protein. The multivalency of LCB1‐NPs and LCB3‐NPs offers a strategy for efficiently targeting and neutralizing SARS‐CoV‐2 both in solution and when immobilized on surfaces. It is demonstrated that LCB1‐NPs and LCB3‐NPs bind to the SARS‐CoV‐2 spike protein's receptor‐binding domain (RBD) with high affinity, effectively blocking the entry of SARS‐CoV‐2 virus‐like particles into angiotensin‐converting enzyme 2 (ACE2)‐coated human cells. The cost‐effectiveness, scalability, and straightforward production process of these protein nanoparticles make them suitable for developing novel anti‐viral materials. Accordingly, it is shown how these nanostructures can be packed into columns to build up economic and highly potent trapping devices for SARS‐CoV‐2 adsorption.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Protein Nanoparticles for Targeted SARS‐CoV‐2 Trapping and Neutralization ; day:14 ; month:10 ; year:2024 ; extent:15 ; Advanced healthcare materials ; (14.10.2024) (gesamt 15)

Beteiligte, Orts- und Zeitangaben

• Urheber: Fornt‐Suñé, Marc ; Puertas, Maria C. ; Martinez‐Picado, Javier ; García‐Pardo, Javier ; Ventura, Salvador

Weitere Informationen

• DOI: 10.1002/adhm.202402744
• URN: urn:nbn:de:101:1-2410151407130.865296468212
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:37 MESZ