The association of folate deficiency with clinical and radiological severity of knee osteoarthritis
Context: Folate deficiency is often observed in patients with inflammatory diseases, raising questions about its role in knee osteoarthritis (OA) progression. Objectives: This study aimed to assess the association of folate deficiency with the clinical and radiological severity of knee OA. Methods: A prospective cross-sectional study was conducted from January 1, 2019 to January 1, 2020. Primary knee OA patients referred to orthopedic clinics in Zabol, Iran were included. Radiographic severity was gauged utilizing the Kellgren–Lawrence (KL) classification. For clinical severity, patients completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. IBM SPSS v.27 facilitated the statistical analysis. Results: Forty-nine knee OA patients, averaging 67.45±13.44 years in age, were analyzed. Spearman correlation analysis revealed a negative correlation between folate levels and both WOMAC and KL scores. The correlation was stronger between folate and KL score (Spearman correlation coefficient: −0.75) than between folate and WOMAC total score (Spearman correlation coefficient: −0.46). Additionally, a significantly higher KL score was observed in patients with folate deficiency (p=0.004). Conclusions: Our study highlights a significant correlation between folate deficiency and increased severity of OA, which is evident in radiological and clinical assessments. These findings suggest that folate plays a key role in OA pathogenesis and could be a modifiable factor in its management.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The association of folate deficiency with clinical and radiological severity of knee osteoarthritis ; volume:124 ; number:5 ; year:2024 ; pages:213-218 ; extent:06
Journal of osteopathic medicine ; 124, Heft 5 (2024), 213-218 (gesamt 06)
- Creator
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Abedi, Majid
Mollashahi Javan, Hasan
Khosravi, Asal
Rohani, Reza
Mohammadsharifi, Ghasem
- DOI
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10.1515/jom-2023-0030
- URN
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urn:nbn:de:101:1-2404231535181.456417906032
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:52 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Abedi, Majid
- Mollashahi Javan, Hasan
- Khosravi, Asal
- Rohani, Reza
- Mohammadsharifi, Ghasem
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The second study of experimental human folate deficiency
Relationship between radiological severity and physical and mental health in elderly individuals with knee osteoarthritis
Protective effects of pyrroloquinoline quinone in brain folate deficiency
Association of serum uric acid with clinical and radiological severity of knee osteoarthritis in non-gouty patients
Urinary C-terminal telopeptide of type II collagen, radiological severity, and functional assessment in knee osteoarthritis: are these related?
Effects of folate deficiency on HPV16E6E7-immortalized human keratinocytes : implications for carcinogenesis
Marginal Folate Deficiency as a Possible Cause of Hyperhomocysteinaemia in Stroke Patients
Comparison of MRI Osteoarthritis Knee Score with Clinico-Radiological Grading
Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature
Radiological changes in shoulder osteoarthritis and pain sensation correlate with patients’ age
Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells
Association between radiological findings and severity of community-acquired pneumonia in children
The second study of experimental human folate deficiency
Relationship between radiological severity and physical and mental health in elderly individuals with knee osteoarthritis
Protective effects of pyrroloquinoline quinone in brain folate deficiency
Association of serum uric acid with clinical and radiological severity of knee osteoarthritis in non-gouty patients
Urinary C-terminal telopeptide of type II collagen, radiological severity, and functional assessment in knee osteoarthritis: are these related?
Effects of folate deficiency on HPV16E6E7-immortalized human keratinocytes : implications for carcinogenesis
Marginal Folate Deficiency as a Possible Cause of Hyperhomocysteinaemia in Stroke Patients
Comparison of MRI Osteoarthritis Knee Score with Clinico-Radiological Grading
Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature
Radiological changes in shoulder osteoarthritis and pain sensation correlate with patients’ age
Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells