Occurrence of Thromboembolic Events and Mortality Among Hospitalized COVID-19 Patients: Large Observational Cohort Study of Electronic Health Records

Background: Most symptoms of COVID-19 are mild; however, some patients experience cardiovascular complications, including thromboembolic events and death. Data are needed to better inform prevention and treatment of these events. This analysis was designed to describe patient characteristics, medication use, thromboembolic events, and all-cause mortality in hospitalized COVID-19 patients in the United States. Methods: This retrospective, observational cohort study identified adults hospitalized with COVID-19 (01/21/2020-01/07/2021) in the de-identified Optum® COVID-19 Electronic Health Records dataset. Thromboembolic events and all-cause mortality were collected at any time during the variable follow-up period (up to 50 weeks). Results: Of 181,995 COVID-19 patients who met eligibility criteria, 40,524 (22.3%) were hospitalized with COVID-19. Hospitalized patients had a mean age of 63 years and a Quan-Charlson comorbidity index of 1.3. Anticoagulants were used in 89.2% of patients during hospitalization and in 18.7% of post-discharge patients. Of hospitalized patients, 17.6% had a thromboembolic event during the entire follow-up period (mean time to first event of 15 days), of whom 13.4% had an event during hospitalization; of discharged patients, 4.3% had a thromboembolic event (mean time from discharge to event of 43 days). Death during the follow-up period was reported in 15.0% of patients. Conclusions: In this large, observational cohort study, patients hospitalized with COVID-19 had high rates of thromboembolic events during hospitalization and in the post-discharge period; mortality was also high in this population. Anticoagulant use was common during hospitalization. These findings support further study to optimize in-hospital and extended prophylaxis for hospitalized COVID-19 patients.

Object Details

• Alternative title: Thromboembolism in Hospitalized COVID-19 Patients
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Occurrence of Thromboembolic Events and Mortality Among Hospitalized COVID-19 Patients: Large Observational Cohort Study of Electronic Health Records ; day:07 ; month:09 ; year:2022 ; TH open ; (07.09.2022)

Contributors, Places and Time

• Contributor: Spyropoulos, Alex C. ; Crawford, James M. ; Chen, Yen-Wen ; Ashton, Veronica ; Campbell, Alicia K. ; Milentijevic, Dejan ; Peacock, W. Frank

Further information

• DOI: 10.1055/a-1937-9692
• URN: urn:nbn:de:101:1-2022111710114995761883
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST