Human Gut Antibiotic Resistome and Progression of Diabetes
Abstract: The antibiotic resistance crisis underlies globally increasing failures in treating deadly bacterial infections, largely due to the selection of antibiotic resistance genes (ARG) collection, known as the resistome, in human gut microbiota. So far, little is known about the relationship between gut antibiotic resistome and host metabolic disorders such as type 2 diabetes (T2D). Here, metagenomic landscape of gut antibiotic resistome is profiled in a large multiomics human cohort (n = 1210). There is a significant overall shift in gut antibiotic resistome structure among healthy, prediabetes, and T2D groups. It is found that larger ARG diversity is associated with a higher risk of T2D. The novel diabetes ARG score is positively associated with glycemic traits. Longitudinal validation analysis confirms that the ARG score is associated with T2D progression, characterized by the change of insulin resistance. Collectively, the data describe the profiles of gut antibiotic resistome and support its close relationship with T2D progression.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Human Gut Antibiotic Resistome and Progression of Diabetes ; day:10 ; month:02 ; year:2022 ; extent:14
Advanced science ; (10.02.2022) (gesamt 14)
- Urheber
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Shuai, Menglei
Zhang, Guoqing
Zeng, Fang‐fang
Fu, Yuanqing
Liang, Xinxiu
Yuan, Ling
Xu, Fengzhe
Gou, Wanglong
Miao, Zelei
Jiang, Zengliang
Wang, Jia‐ting
Zhuo, Lai‐bao
Chen, Yu‐ming
Ju, Feng
Zheng, Ju-Sheng
- DOI
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10.1002/advs.202104965
- URN
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urn:nbn:de:101:1-2022021014244977068457
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:33 MESZ
Datenpartner
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Beteiligte
- Shuai, Menglei
- Zhang, Guoqing
- Zeng, Fang‐fang
- Fu, Yuanqing
- Liang, Xinxiu
- Yuan, Ling
- Xu, Fengzhe
- Gou, Wanglong
- Miao, Zelei
- Jiang, Zengliang
- Wang, Jia‐ting
- Zhuo, Lai‐bao
- Chen, Yu‐ming
- Ju, Feng
- Zheng, Ju-Sheng
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