Fast Delivery of Multifunctional NIR‐II Theranostic Nanoaggregates Enabled by the Photoinduced Thermoacoustic Process
Abstract: Multifunctional nanoaggregates are widely used in cancer phototheranostics. However, it is challenging to construct their multifunctionality with a single component, and deliver them rapidly and efficiently without complex modifications. Herein, a NIR‐absorbing small molecule named TBT‐2 (TP‐DPA) is designed and certify its theranostic potentials. Then, their nanoaggregates, which are simply encapsulated by DSPE‐PEG, demonstrate a photothermal efficiency of 51% while keeping a high photoluminescence quantum yield in the NIR region. Moreover, the nanoaggregates can be excited and delivered by an 808 nm pulse laser to solid tumors within only 40 min. The delivery efficiency and theranostic efficacy are better than that of the traditional enhanced permeability and retention (EPR) effect (generally longer than 24 hours). This platform is first termed as the photoinduced thermoacoustic (PTA) process, and confirm its application requires both NIR‐responsive materials and pulse laser irradiation. This study not only inspires the design of multifunctional nanoaggregates, but also offers a feasible approach to their fast delivery. The platform reported here provides a promising prospect to boost the development of multifunctional theranostic drugs and maximize the efficacy of used medicines for their clinical applications.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Fast Delivery of Multifunctional NIR‐II Theranostic Nanoaggregates Enabled by the Photoinduced Thermoacoustic Process ; day:23 ; month:04 ; year:2023 ; extent:11
Advanced science ; (23.04.2023) (gesamt 11)
- Urheber
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Xie, Huilin
Zhang, Chen
Li, Tingting
Hu, Lianrui
Zhang, Jianquan
Guo, Heng
Liu, Zhao
Peng, Dinglu
Li, Zeshun
Wu, Weijun
Gao, Ji
Bi, Zhenyu
Wang, Jinghan
Zhang, Pengfei
Kwok, Ryan T. K.
Lam, Jacky W. Y.
Guo, Zhihong
Xi, Lei
Li, Kai
Tang, Ben Zhong
- DOI
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10.1002/advs.202301104
- URN
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urn:nbn:de:101:1-2023042515203309215961
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 11:01 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Xie, Huilin
- Zhang, Chen
- Li, Tingting
- Hu, Lianrui
- Zhang, Jianquan
- Guo, Heng
- Liu, Zhao
- Peng, Dinglu
- Li, Zeshun
- Wu, Weijun
- Gao, Ji
- Bi, Zhenyu
- Wang, Jinghan
- Zhang, Pengfei
- Kwok, Ryan T. K.
- Lam, Jacky W. Y.
- Guo, Zhihong
- Xi, Lei
- Li, Kai
- Tang, Ben Zhong
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