Weight Loss after Endoscopic Sleeve Gastroplasty is Independent of the Suture Pattern: Results from a Randomized Controlled Trial.

Background and study aims: Single-blind, single-center prospective randomized trial aiming to compare the efficacy of three different suturing patterns of endoscopic sleeve gastroplasty using Endomina (E-ESG). Materials and methods: The suture patterns aimed to modify gastric accommodation by increasing the fundus distention ability (group A), to reduce gastric volume (group B) or to interrupt gastric emptying (group C). Patients were 1:1:1 randomized and underwent clinical follow-up, gastric emptying scintigraphy and satiety tests at baseline, 6, and 12 months post-procedure. The primary outcome was total body weight loss (TBWL) and excess weight loss (EWL) at 12 months post-procedure. Secondary outcomes included the impact of the suturing patterns on gastric emptying and satiety. Results: Overall, 48 patients (40 [83.3%] female, age 41.9±9.5 years, BMI 33.8±2.7 kg/m2) were randomized (16 in each group). In the entire cohort, mean (95%CI) TBWL and EWL at the end of the follow-up were 10.11% (7.1-13.12) and 42.56 (28.23-56.9), respectively. There was no difference among the three study groups in terms of TBWL (95%CI) (9.13% [2.16-16.11] vs. 11.29% [5.79-16.80] vs. 9.96% [4.58-15.35]; p=0.589) and EWL (95%CI) (34.54% [6.09-62.99] vs. 44.75% [23.63-65.88] vs. 46.94% [16.72-77.15]; p=0.888) at 12 months post-procedure. The three groups did not differ in terms of mean gastric emptying time or in terms of satiety tests at the end of the follow-up. No serious adverse events occurred. Conclusions: Three different suture patterns during E-ESG demonstrated comparable efficacy in terms of weight loss, with an overall EWL of >25% and TBWL of >10% at 12 months.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Weight Loss after Endoscopic Sleeve Gastroplasty is Independent of the Suture Pattern: Results from a Randomized Controlled Trial. ; day:21 ; month:06 ; year:2022 ; Endoscopy International Open ; (21.06.2022)

Contributors, Places and Time

• Contributor: Gkolfakis, Paraskevas ; Van Ouytsel, Pauline ; Mourabit, Youssef ; Fernandez Y Viesca, Michael ; Yared, Rawad ; Devière, Jacques ; Huberty, Vincent

Further information

• DOI: 10.1055/a-1880-7580
• URN: urn:nbn:de:101:1-2022080408464763908646
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:27 AM CEST