The evoked compound nerve action potential is shaped by the electrical pulse-width
Abstract: Introduction: Despite its central role in medicine electrical stimulation (ES) is still limited by its selectivity. Different reports did assess effects of different waveforms, intensities, and frequency on the activation threshold of nerve fibres with different diameters. We aimed to extend this knowledge by investigating the effect of short monophasic rectangular pulses (1, 2, 5, 10, 50, 100 and 200 μs) on the recruitment order. Methods:The sciatic nerve of rats was stimulated, and the evoked compound nerve action potential (CNAP) measured at two sites on the tibialis nerve, using epineural electrodes. Changes in delay, amplitude, and the shape of the CNAP were analyzed. Results:The amplitude and delay of the CNAP were significantly affected by the pulse-width (PW). The delay and duration of the compound nerve action potential increased with longer PW, while the amplitude decreased. Discussion:Found changes are likely caused by changes in the time point of excitation of individual neuron fibres, depending on electrical field strength and exposure time. This might be of particular interest when selecting PWs for design and validation of stimulation patterns and analysis of experimental and clinical observations.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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The evoked compound nerve action potential is shaped by the electrical pulse-width ; volume:8 ; number:3 ; year:2022 ; pages:37-40 ; extent:4
Current directions in biomedical engineering ; 8, Heft 3 (2022), 37-40 (gesamt 4)
- Urheber
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Proksch, Johannes
Vargas Luna, Jose Luis
Eickhoff, Steffen
Mayr, Winfried
Jarvis, Jonathan C.
- DOI
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10.1515/cdbme-2022-2010
- URN
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urn:nbn:de:101:1-2022090614114853930792
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:24 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Proksch, Johannes
- Vargas Luna, Jose Luis
- Eickhoff, Steffen
- Mayr, Winfried
- Jarvis, Jonathan C.
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