Evaluation of loading behavior of a selfexpanding polymeric microstent for the treatment of Fallopian tube occlusions
Abstract: Female sterility is caused by Fallopian tube occlusions in one of three cases. Current treatment methods achieve unsatisfying pregnancy rates and are associated with high costs or significant psychological and physiological stress. Our previously described microstent technology opens up new therapeutic possibilities to restore the lumen of the Fallopian tube without surgery. In this work, a Finite Element Analysis model of a physiologically relevant loading of the device is presented. Therefore, microstent radial force was analysed as a function of the device diameter up to a minimum diameter of 1.4 mm, which was found after microstent implantation ex vivo. A bilinear constitutive material model considering isotropic hardening was used for modeling of the microstent. The Finite Element Analysis results were validated using corresponding results of experimental investigations. In this context, a maximum deviation of 15% between experimental radial force and the corresopnding simulation results (1.33 N vs. 1.13 N) was found. Maximum von Mises stresses of approximately 88 MPa were determined. A good agreement between simulation and experiments was found. Therefore, future simulations will be carried out as a basis for microstent design optimisation.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Evaluation of loading behavior of a selfexpanding polymeric microstent for the treatment of Fallopian tube occlusions ; volume:9 ; number:1 ; year:2023 ; pages:607-610 ; extent:4
Current directions in biomedical engineering ; 9, Heft 1 (2023), 607-610 (gesamt 4)
- Creator
-
Dierke, Ariane
Supp, Laura
Paetow, Hagen
Stahnke, Thomas
Stiehm, Michael
Bock, Andrea
Schmitz, Klaus-Peter
Siewert, Stefan
Rosam, Paula
Knorre, Luise
Zygmunt, Marek
- DOI
-
10.1515/cdbme-2023-1152
- URN
-
urn:nbn:de:101:1-2023092214053548899785
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:51 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Dierke, Ariane
- Supp, Laura
- Paetow, Hagen
- Stahnke, Thomas
- Stiehm, Michael
- Bock, Andrea
- Schmitz, Klaus-Peter
- Siewert, Stefan
- Rosam, Paula
- Knorre, Luise
- Zygmunt, Marek
Other Objects (12)
Design optimization of a self-expanding polymeric microstent for the treatment of Fallopian tube occlusions
Validation of Finite Element Analysis of a selfexpanding polymeric microstent for treatment of Fallopian tube occlusions
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Microstent for minimally invasive treatment of Fallopian tube occlusions – porcine implantation ex vivo
Perspektiven aus den Technikwissenschaften bzw. der Medizintechnik
Plädoyer für Forschungsverbünde in der Wissenschaft : Perspektiven aus den Technikwissenschaften und der Medizintechnik
Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions
Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions
Numerical design studies of meander structures for self-expanding absorbable stents
A numerical study to investigate the impact of cell size of self-expanding aortic valve stents on paravalvular leakage
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Design optimization of a self-expanding polymeric microstent for the treatment of Fallopian tube occlusions
Validation of Finite Element Analysis of a selfexpanding polymeric microstent for treatment of Fallopian tube occlusions
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Microstent for minimally invasive treatment of Fallopian tube occlusions – porcine implantation ex vivo
Perspektiven aus den Technikwissenschaften bzw. der Medizintechnik
Plädoyer für Forschungsverbünde in der Wissenschaft : Perspektiven aus den Technikwissenschaften und der Medizintechnik
Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions
Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions
Numerical design studies of meander structures for self-expanding absorbable stents
A numerical study to investigate the impact of cell size of self-expanding aortic valve stents on paravalvular leakage
Electrospinning of polyimide nanofibres – effects of working parameters on morphology
Method for the improvement of mechanical properties of biodegradable polymeric scaffolds
Design optimization of a self-expanding polymeric microstent for the treatment of Fallopian tube occlusions
Validation of Finite Element Analysis of a selfexpanding polymeric microstent for treatment of Fallopian tube occlusions
Reconstruction of biological functions: novel implant concepts for cardiovascular, ophthal-mologic and otolaryngologic applications : Current research and development activities of the Twenty20 consortium RESPONSE
Microstent for minimally invasive treatment of Fallopian tube occlusions – porcine implantation ex vivo
Perspektiven aus den Technikwissenschaften bzw. der Medizintechnik
Plädoyer für Forschungsverbünde in der Wissenschaft : Perspektiven aus den Technikwissenschaften und der Medizintechnik
Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions
Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions
Numerical design studies of meander structures for self-expanding absorbable stents
A numerical study to investigate the impact of cell size of self-expanding aortic valve stents on paravalvular leakage
Electrospinning of polyimide nanofibres – effects of working parameters on morphology