Proton Pump Inhibitors: Rational Use and Use-Reduction – The Windsor Workshop

Abstract: Background: Despite deprescribing initiatives to curb overutilization of proton pump inhibitors (PPIs), achieving meaningful reductions in PPI use is proving a challenge. Summary: An international group of primary care doctors and gastroenterologists examined the literature surrounding PPI use and use-reduction to clarify: (i) what constitutes rational PPI prescribing; (ii) when and in whom PPI use-reduction should be attempted; and (iii) what strategies to use when attempting PPI use-reduction. Key Messages: Before starting a PPI for reflux-like symptoms, patients should be educated on potential causes and alternative approaches including dietary and lifestyle modification, weight loss, and relaxation strategies. When commencing a PPI, patients should understand the reason for treatment, planned duration, and review date. PPI use at hospital discharge should not be continued without a recognized indication for long-term treatment. Long-term PPI therapy should be reviewed at least annually. PPI use-reduction should be based on the lack of a rational indication for long-term PPI use, not concern for PPI-associated adverse events. PPI use-reduction strategies involving switching to on-demand PPI or dose tapering, with rescue therapy for rebound symptoms, are more likely to succeed than abrupt cessation.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Proton Pump Inhibitors: Rational Use and Use-Reduction – The Windsor Workshop ; volume:42 ; number:3 ; year:2024 ; pages:211-220 ; extent:10 ; Digestive diseases ; 42, Heft 3 (2024), 211-220 (gesamt 10)

Contributors, Places and Time

• Creator: Kahrilas, Peter ; Anastasiou, Foteini ; Bredenoord, Albert J. ; El Serag, Hashem B. ; Labenz, Joachim ; Mendive, Juan ; Savarino, Edoardo V. ; Sifrim, Daniel ; Udrescu, Mihaela ; Yadlapati, Rena ; Hungin, A. Pali

Further information

• DOI: 10.1159/000538399
• URN: urn:nbn:de:101:1-2406130029118.298405964391
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:57 AM CEST