Fructooligosaccharides Intake during Pregnancy Improves Metabolic Phenotype of Offspring in High Fat Diet‐Induced Obese Mice
Scope: Obesity and metabolic diseases are closely associated, and individuals who become obese are also prone to type 2 diabetes and cardiovascular disorders. Gut microbiota is mediated by diet and can influence host metabolism and the incidence of metabolic disorders. Recent studies have suggested that improving gut microbiota through a fructooligosaccharide (FOS)‐supplemented diet may ameliorate obesity and other metabolic disorders. Although accumulating evidence supports the notion of the developmental origins of health and disease, the underlying mechanisms remain obscure. Methods and results: ICR mice are fed AIN‐93G formula‐based cellulose –, FOS–, acetate–, or propionate‐supplemented diets during pregnancy. Offspring are reared by conventional ICR foster mothers for 4 weeks; weaned mice are fed high fat diet for 12 weeks and housed individually. The FOS and propionate offspring contribute to suppressing obesity and improving glucose intolerance. Gut microbial compositions in FOS‐fed mothers and their offspring are markedly changed. However, the beneficial effect of FOS diet on the offspring is abolished when antibiotics are administered to pregnant mice. Conclusion: The findings highlight the link between the maternal gut environment and the developmental origin of metabolic syndrome in offspring. These results open novel research avenues into preemptive therapies for metabolic disorders by targeting the maternal gut microbiota.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Fructooligosaccharides Intake during Pregnancy Improves Metabolic Phenotype of Offspring in High Fat Diet‐Induced Obese Mice ; day:19 ; month:04 ; year:2024 ; extent:8
Molecular nutrition & food research ; (19.04.2024) (gesamt 8)
- Creator
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Miyamoto, Junki
Ando, Yuna
Nishida, Akari
Yamano, Mayu
Suzuki, Shunsuke
Takada, Hiromi
Kimura, Ikuo
- DOI
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10.1002/mnfr.202300758
- URN
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urn:nbn:de:101:1-2404191427518.840042413080
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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03.08.20232023, 6:25 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Miyamoto, Junki
- Ando, Yuna
- Nishida, Akari
- Yamano, Mayu
- Suzuki, Shunsuke
- Takada, Hiromi
- Kimura, Ikuo
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