An integrated database of small RNAs and their interplay with transcriptional gene regulatory networks in corynebacteria
Abstract: Small RNAs (sRNAs) are one of the key players in the post-transcriptional regulation of bacterial gene expression. These molecules, together with transcription factors, form regulatory networks and greatly influence the bacterial regulatory landscape. Little is known concerning sRNAs and their influence on the regulatory machinery in the genus Corynebacterium, despite its medical, veterinary and biotechnological importance. Here, we expand corynebacterial regulatory knowledge by integrating sRNAs and their regulatory interactions into the transcriptional regulatory networks of six corynebacterial species, covering four human and animal pathogens, and integrate this data into the CoryneRegNet database. To this end, we predicted sRNAs to regulate 754 genes, including 206 transcription factors, in corynebacterial gene regulatory networks. Amongst them, the sRNA Cd-NCTC13129-sRNA-2 is predicted to directly regulate ydfH, which indirectly regulates 66 genes, including the global regulator glxR in C. diphtheriae. All of the sRNA-enriched regulatory networks of the genus Corynebacterium have been made publicly available in the newest release of CoryneRegNet(www.exbio.wzw.tum.de/coryneregnet/) to aid in providing valuable insights and to guide future experiments
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Frontiers in microbiology. - 12 (2021) , 656435, ISSN: 1664-302X
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2021
- Creator
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Parise, Mariana Teixeira Dornelles
Parise, Doglas
Aburjaile, Flavia Figueira
Pinto Gomide, Anne Cybelle
Kato, Rodrigo Bentes
Raden, Martin
Backofen, Rolf
Azevedo, Vasco
Baumbach, Jan
- DOI
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10.3389/fmicb.2021.656435
- URN
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urn:nbn:de:bsz:25-freidok-2202943
- Rights
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:48 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Parise, Mariana Teixeira Dornelles
- Parise, Doglas
- Aburjaile, Flavia Figueira
- Pinto Gomide, Anne Cybelle
- Kato, Rodrigo Bentes
- Raden, Martin
- Backofen, Rolf
- Azevedo, Vasco
- Baumbach, Jan
- Universität
Time of origin
- 2021
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